"Cortactin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microfilament protein that interacts with F-ACTIN and regulates cortical actin assembly and organization. It is also an SH3 DOMAIN containing phosphoprotein, and it mediates tyrosine PHOSPHORYLATION based SIGNAL TRANSDUCTION by PROTO-ONCOGENE PROTEIN PP60(C-SRC).
| Descriptor ID |
D051356
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| MeSH Number(s) |
D05.750.078.730.281 D12.644.360.024.280 D12.776.157.057.014 D12.776.220.525.281 D12.776.476.024.311 D12.776.744.390
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cortactin".
Below are MeSH descriptors whose meaning is more specific than "Cortactin".
This graph shows the total number of publications written about "Cortactin" by people in this website by year, and whether "Cortactin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cortactin" by people in Profiles.
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Cortactin expression in non-Hodgkin B-cell lymphomas: a new marker for the differential diagnosis between chronic lymphocytic leukemia and mantle cell lymphoma. Hum Pathol. 2019 03; 85:251-259.
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Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics. Chem Commun (Camb). 2018 Jun 26; 54(52):7151-7154.
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Oncogenic BRAF-Mediated Melanoma Cell Invasion. Cell Rep. 2016 05 31; 15(9):2012-24.
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Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration. Mol Endocrinol. 2015 Feb; 29(2):200-12.
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Role of the focal adhesion protein TRIM15 in colon cancer development. Biochim Biophys Acta. 2015 Feb; 1853(2):409-21.
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miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression. Cancer Res. 2014 Nov 01; 74(21):6280-90.
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Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2193-202.
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HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007 Jul 20; 27(2):197-213.
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Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Res. 2004 Oct 15; 64(20):7302-10.