MTOR Associated Protein, LST8 Homolog
"MTOR Associated Protein, LST8 Homolog" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and MTORC2 COMPLEX. It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity.
| Descriptor ID |
D000076242
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| MeSH Number(s) |
D05.500.337.250 D08.811.913.696.620.682.700.931.500.250 D12.644.360.024.310 D12.776.157.057.073 D12.776.476.024.389 D12.776.476.925.500.250
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "MTOR Associated Protein, LST8 Homolog".
- Chemicals and Drugs [D]
- Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
- Mechanistic Target of Rapamycin Complex 1 [D05.500.337]
- MTOR Associated Protein, LST8 Homolog [D05.500.337.250]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
- TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
- Mechanistic Target of Rapamycin Complex 1 [D08.811.913.696.620.682.700.931.500]
- MTOR Associated Protein, LST8 Homolog [D08.811.913.696.620.682.700.931.500.250]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- MTOR Associated Protein, LST8 Homolog [D12.644.360.024.310]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- MTOR Associated Protein, LST8 Homolog [D12.776.157.057.073]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- MTOR Associated Protein, LST8 Homolog [D12.776.476.024.389]
- TOR Serine-Threonine Kinases [D12.776.476.925]
- Mechanistic Target of Rapamycin Complex 1 [D12.776.476.925.500]
- MTOR Associated Protein, LST8 Homolog [D12.776.476.925.500.250]
Below are MeSH descriptors whose meaning is more specific than "MTOR Associated Protein, LST8 Homolog".
This graph shows the total number of publications written about "MTOR Associated Protein, LST8 Homolog" by people in this website by year, and whether "MTOR Associated Protein, LST8 Homolog" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "MTOR Associated Protein, LST8 Homolog" by people in Profiles.
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell. 2003 Apr; 11(4):895-904.