Regulatory-Associated Protein of mTOR
"Regulatory-Associated Protein of mTOR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adaptor protein component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 that forms stoichiometric complexes with TOR KINASES, which it negatively regulates. It functions as a positive regulator of RIBOSOMAL PROTEIN S6 KINASES.
| Descriptor ID |
D000076223
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| MeSH Number(s) |
D05.500.337.500 D08.811.913.696.620.682.700.931.500.500 D12.644.360.024.324 D12.776.157.057.157 D12.776.476.024.419 D12.776.476.925.500.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Regulatory-Associated Protein of mTOR".
Below are MeSH descriptors whose meaning is more specific than "Regulatory-Associated Protein of mTOR".
This graph shows the total number of publications written about "Regulatory-Associated Protein of mTOR" by people in this website by year, and whether "Regulatory-Associated Protein of mTOR" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Regulatory-Associated Protein of mTOR" by people in Profiles.
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Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice. Biochem Biophys Res Commun. 2018 11 10; 505(4):1174-1179.
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Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine. Sci Rep. 2017 07 17; 7(1):5580.
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Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes. FASEB J. 2017 09; 31(9):3934-3949.
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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood. 2007 Apr 15; 109(8):3509-12.
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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 06; 127(1):125-37.