Interferon-Stimulated Gene Factor 3
"Interferon-Stimulated Gene Factor 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
| Descriptor ID |
D050832
|
| MeSH Number(s) |
D12.644.360.024.303 D12.776.157.057.061 D12.776.260.513 D12.776.476.024.386 D12.776.930.354
|
| Concept/Terms |
Interferon-Stimulated Gene Factor 3- Interferon-Stimulated Gene Factor 3
- Interferon Stimulated Gene Factor 3
- Transcription Factor ISGF3
- ISGF3, Transcription Factor
- ISGF3 Transcription Factor
- Transcription Factor, ISGF3
- IFN-Stimulated Gene Factor 3 Complex
- IFN Stimulated Gene Factor 3 Complex
- ISGF3 Factor
|
Below are MeSH descriptors whose meaning is more general than "Interferon-Stimulated Gene Factor 3".
Below are MeSH descriptors whose meaning is more specific than "Interferon-Stimulated Gene Factor 3".
This graph shows the total number of publications written about "Interferon-Stimulated Gene Factor 3" by people in this website by year, and whether "Interferon-Stimulated Gene Factor 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interferon-Stimulated Gene Factor 3" by people in Profiles.
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Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Virol J. 2005 Sep 07; 2:80.
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Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis. Clin Cancer Res. 2002 Jul; 8(7):2067-72.
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Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. Biol Reprod. 2002 Feb; 66(2):393-400.
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Overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells. Cancer Res. 2001 Sep 01; 61(17):6540-7.
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Impaired alpha-interferon signaling in transitional cell carcinoma: lack of p48 expression in 5637 cells. Cancer Res. 2001 Mar 01; 61(5):2261-6.
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Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells. Endocrinology. 2001 Jan; 142(1):98-107.
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Expression of protein mediators of type I interferon signaling in human squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev. 2000 Sep; 9(9):993-7.
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Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol. 1998 Nov 01; 161(9):4803-10.