Heterogeneous-Nuclear Ribonucleoprotein K
"Heterogeneous-Nuclear Ribonucleoprotein K" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
| Descriptor ID |
D034641
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| MeSH Number(s) |
D12.776.157.725.813.750.500 D12.776.260.268 D12.776.664.962.813.750.500
|
| Concept/Terms |
hnRNP K Protein- hnRNP K Protein
- Heterogeneous Nuclear Ribonucleoprotein Particle K Protein
- dC-Stretch-Binding Protein
- dC Stretch Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Heterogeneous-Nuclear Ribonucleoprotein K".
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This graph shows the total number of publications written about "Heterogeneous-Nuclear Ribonucleoprotein K" by people in this website by year, and whether "Heterogeneous-Nuclear Ribonucleoprotein K" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Heterogeneous-Nuclear Ribonucleoprotein K" by people in Profiles.
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The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020 03 18; 48(5):2621-2642.
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Antibodies against heterogeneous nuclear ribonucleoprotein K in patients with cardiac allograft vasculopathy. J Heart Lung Transplant. 2011 Sep; 30(9):1051-9.
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Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10. PLoS Genet. 2010 Jun 10; 6(6):e1000984.
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Growth factors regulate heterogeneous nuclear ribonucleoprotein K expression and function. J Biol Chem. 2001 Mar 30; 276(13):9699-704.