Heterogeneous-Nuclear Ribonucleoprotein K
"Heterogeneous-Nuclear Ribonucleoprotein K" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
| Descriptor ID |
D034641
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| MeSH Number(s) |
D12.776.157.725.813.750.500 D12.776.260.268 D12.776.664.962.813.750.500
|
| Concept/Terms |
hnRNP K Protein- hnRNP K Protein
- Heterogeneous Nuclear Ribonucleoprotein Particle K Protein
- dC-Stretch-Binding Protein
- dC Stretch Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Heterogeneous-Nuclear Ribonucleoprotein K".
Below are MeSH descriptors whose meaning is more specific than "Heterogeneous-Nuclear Ribonucleoprotein K".
This graph shows the total number of publications written about "Heterogeneous-Nuclear Ribonucleoprotein K" by people in this website by year, and whether "Heterogeneous-Nuclear Ribonucleoprotein K" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Heterogeneous-Nuclear Ribonucleoprotein K" by people in Profiles.
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Insight into the mechanism of AML del(9q) progression: hnRNP K targets the myeloid master regulators CEBPA (C/EBPa) and SPI1 (PU.1). Biochim Biophys Acta Gene Regul Mech. 2024 Mar; 1867(1):195004.
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Assessing the role of intrinsic disorder in RNA-binding protein function: hnRNP K as a case study. Methods. 2022 12; 208:59-65.
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The E?-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies. Front Immunol. 2021; 12:634584.
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The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020 03 18; 48(5):2621-2642.
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Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas. J Natl Cancer Inst. 2020 01 01; 112(1):95-106.
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A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud. Genet Med. 2020 01; 22(1):189-198.
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Aberrant hnRNP K expression: All roads lead to cancer. Cell Cycle. 2016 Jun 17; 15(12):1552-7.
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hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell. 2015 Oct 12; 28(4):486-499.
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Antibodies against heterogeneous nuclear ribonucleoprotein K in patients with cardiac allograft vasculopathy. J Heart Lung Transplant. 2011 Sep; 30(9):1051-9.
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Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10. PLoS Genet. 2010 Jun 10; 6(6):e1000984.