"MRE11 Homologue Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
| Descriptor ID |
D000076228
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| MeSH Number(s) |
D08.811.277.352.335.350.650 D08.811.277.352.335.375.813 D08.811.277.352.355.325.600 D08.811.277.352.365.290.250 D12.776.157.687.495 D12.776.260.539 D12.776.660.720.495
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| Concept/Terms |
MRE11 Homologue Protein- MRE11 Homologue Protein
- Homologue Protein, MRE11
- MRE11A Protein
- Meiotic Recombination 11 Homolog 1 Protein
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Below are MeSH descriptors whose meaning is more general than "MRE11 Homologue Protein".
Below are MeSH descriptors whose meaning is more specific than "MRE11 Homologue Protein".
This graph shows the total number of publications written about "MRE11 Homologue Protein" by people in this website by year, and whether "MRE11 Homologue Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "MRE11 Homologue Protein" by people in Profiles.
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MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells. Nat Commun. 2017 10 16; 8(1):860.
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Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem. 2013 Mar 01; 288(9):6342-50.
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MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. Cancer Res. 2011 Apr 01; 71(7):2632-42.
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MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem. 2010 Jan 08; 285(2):1097-104.
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N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem. 2009 Nov 13; 284(46):31746-52.
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A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol. 2009 Jun; 29(11):2982-96.
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Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines. Br J Cancer. 2008 Nov 18; 99(10):1607-12.
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ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. Cancer Res. 2008 Oct 01; 68(19):7947-55.
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MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11200-5.
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Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene. 2008 Aug 28; 27(37):5045-56.