"MRE11 Homologue Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
| Descriptor ID |
D000076228
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| MeSH Number(s) |
D08.811.277.352.335.350.650 D08.811.277.352.335.375.813 D08.811.277.352.355.325.600 D08.811.277.352.365.290.250 D12.776.157.687.495 D12.776.260.539 D12.776.660.720.495
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| Concept/Terms |
MRE11 Homologue Protein- MRE11 Homologue Protein
- Homologue Protein, MRE11
- MRE11A Protein
- Meiotic Recombination 11 Homolog 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "MRE11 Homologue Protein".
Below are MeSH descriptors whose meaning is more specific than "MRE11 Homologue Protein".
This graph shows the total number of publications written about "MRE11 Homologue Protein" by people in this website by year, and whether "MRE11 Homologue Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "MRE11 Homologue Protein" by people in Profiles.
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GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nat Commun. 2024 Mar 08; 15(1):2132.
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MRNIP condensates promote DNA double-strand break sensing and end resection. Nat Commun. 2022 05 12; 13(1):2638.
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PD-L1 and MRN synergy in platinum-based chemoresistance of head and neck squamous cell carcinoma. Br J Cancer. 2020 03; 122(5):640-647.
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The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair. Annu Rev Biochem. 2018 06 20; 87:263-294.
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Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Methods Enzymol. 2018; 601:205-241.
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MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells. Nat Commun. 2017 10 16; 8(1):860.
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Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017 07 15; 31(14):1469-1482.
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Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair. Prog Biophys Mol Biol. 2015 Mar; 117(2-3):182-193.
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Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer. Clin Cancer Res. 2014 Dec 15; 20(24):6465-78.
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Hyperthermia inhibits recombination repair of gemcitabine-stalled replication forks. J Natl Cancer Inst. 2014 Aug; 106(8).