"Flap Endonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
| Descriptor ID |
D045585
|
| MeSH Number(s) |
D08.811.277.352.355.325.350
|
| Concept/Terms |
Flap Endonuclease-1- Flap Endonuclease-1
- Endonuclease-1, Flap
- Flap Endonuclease 1
- RTH-1 Nuclease
- Nuclease, RTH-1
- RTH 1 Nuclease
- RAD2 Homolog-1 Nuclease
- RAD2 Homolog 1 Nuclease
- FEN-1
- Fen1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Flap Endonucleases".
Below are MeSH descriptors whose meaning is more specific than "Flap Endonucleases".
This graph shows the total number of publications written about "Flap Endonucleases" by people in this website by year, and whether "Flap Endonucleases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Flap Endonucleases" by people in Profiles.
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RPA and Rad27 limit templated and inverted insertions at DNA breaks. Nucleic Acids Res. 2025 Jan 07; 53(1).
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Gallic acid-loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease-1 in triple-negative breast cancer cells. Environ Toxicol. 2024 Aug; 39(8):4171-4183.
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Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymes. Nucleic Acids Res. 2016 Jan 29; 44(2):e15.
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Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem. 2008 Sep 26; 283(39):26349-56.
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Flap endonuclease 1 contributes to telomere stability. Curr Biol. 2008 Apr 08; 18(7):496-500.
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p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11597-602.
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Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA. Biochemistry. 1995 Apr 18; 34(15):5011-7.
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Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I. J Biol Chem. 1994 Nov 18; 269(46):28535-8.