"Flap Endonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
| Descriptor ID |
D045585
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| MeSH Number(s) |
D08.811.277.352.355.325.350
|
| Concept/Terms |
Flap Endonuclease-1- Flap Endonuclease-1
- Endonuclease-1, Flap
- Flap Endonuclease 1
- RTH-1 Nuclease
- Nuclease, RTH-1
- RTH 1 Nuclease
- RAD2 Homolog-1 Nuclease
- RAD2 Homolog 1 Nuclease
- FEN-1
- Fen1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Flap Endonucleases".
Below are MeSH descriptors whose meaning is more specific than "Flap Endonucleases".
This graph shows the total number of publications written about "Flap Endonucleases" by people in this website by year, and whether "Flap Endonucleases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Flap Endonucleases" by people in Profiles.
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RPA and Rad27 limit templated and inverted insertions at DNA breaks. Nucleic Acids Res. 2025 Jan 07; 53(1).
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Gallic acid-loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease-1 in triple-negative breast cancer cells. Environ Toxicol. 2024 Aug; 39(8):4171-4183.
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6.
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Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun. 2017 06 27; 8:15855.
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Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1. Elife. 2017 02 23; 6.
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Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. DNA Repair (Amst). 2015 Nov; 35:106-15.
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Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymes. Nucleic Acids Res. 2016 Jan 29; 44(2):e15.
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Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem. 2015 Jun 12; 290(24):15133-45.
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The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once. DNA Repair (Amst). 2014 Jul; 19:95-107.
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Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8528-33.