"Orphan Nuclear Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.
| Descriptor ID |
D057093
|
| MeSH Number(s) |
D12.776.260.643 D12.776.826.209 D12.776.930.645
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Orphan Nuclear Receptors".
Below are MeSH descriptors whose meaning is more specific than "Orphan Nuclear Receptors".
- Orphan Nuclear Receptors
- COUP Transcription Factors
- Nuclear Receptor Subfamily 1, Group D, Member 1
- Nuclear Receptor Subfamily 1, Group F, Member 1
- Nuclear Receptor Subfamily 1, Group F, Member 2
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Nuclear Receptor Subfamily 2, Group C, Member 1
- Nuclear Receptor Subfamily 2, Group C, Member 2
- Nuclear Receptor Subfamily 4, Group A, Member 1
- Nuclear Receptor Subfamily 4, Group A, Member 2
- Nuclear Receptor Subfamily 4, Group A, Member 3
- Nuclear Receptor Subfamily 6, Group A, Member 1
- Receptors, Aryl Hydrocarbon
This graph shows the total number of publications written about "Orphan Nuclear Receptors" by people in this website by year, and whether "Orphan Nuclear Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 2 | 3 |
| 2014 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Orphan Nuclear Receptors" by people in Profiles.
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The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy. Front Endocrinol (Lausanne). 2023; 14:1229033.
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Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2023784119.
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Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 05; 6(18):eaaz8031.
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The Nuclear Receptor and Clock Repressor Rev-erba Suppresses Myogenesis. Sci Rep. 2019 03 14; 9(1):4585.
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Co-activator candidate interactions for orphan nuclear receptor NR2E1. BMC Genomics. 2016 10 26; 17(1):832.
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Liver X receptor ? controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14006-11.
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Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Mol Cell Endocrinol. 2016 Jan 05; 419:29-43.
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Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab. 2014 Dec; 25(12):649-55.
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The nuclear receptor NR2E1/TLX controls senescence. Oncogene. 2015 Jul 30; 34(31):4069-4077.
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Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. PLoS One. 2014; 9(9):e106289.