Nuclear Receptor Subfamily 4, Group A, Member 2
"Nuclear Receptor Subfamily 4, Group A, Member 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is found at high levels in BRAIN tissue. The protein is believed to play a role in development and maintenance of NEURONS, particularly dopaminergic neurons.
| Descriptor ID |
D057126
|
| MeSH Number(s) |
D12.776.260.643.415 D12.776.826.209.415
|
| Concept/Terms |
Nuclear Receptor Subfamily 4, Group A, Member 2- Nuclear Receptor Subfamily 4, Group A, Member 2
- Nur-Related Factor 1
- Factor 1, Nur-Related
- Nur Related Factor 1
- Nuclear Receptor-Related Factor 1
- Nuclear Receptor Related Factor 1
- Nurr1 Nuclear Receptor
- Orphan Nuclear Receptor Nurr1
- Nuclear Receptor NR4A2
- NR4A2, Nuclear Receptor
- Receptor NR4A2, Nuclear
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 4, Group A, Member 2".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 4, Group A, Member 2".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in this website by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 6 | 6 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in Profiles.
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Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice. Basic Res Cardiol. 2022 07 01; 117(1):33.
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De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay. Am J Hum Genet. 2020 07 02; 107(1):164-172.
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Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1. Structure. 2019 01 02; 27(1):66-77.e5.
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Selective lowering of synapsins induced by oligomeric a-synuclein exacerbates memory deficits. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):E4648-E4657.
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Nuclear receptor 4A (NR4A) family - orphans no more. J Steroid Biochem Mol Biol. 2016 Mar; 157:48-60.
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Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease. CNS Neurol Disord Drug Targets. 2012 Sep; 11(6):768-73.
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SLC22A5/OCTN2 expression in breast cancer is induced by estrogen via a novel intronic estrogen-response element (ERE). Breast Cancer Res Treat. 2012 Jul; 134(1):101-15.
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Nuclear orphan receptor NR4A2 modulates fatty acid oxidation pathways in colorectal cancer. J Biol Chem. 2011 Aug 26; 286(34):30003-9.
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The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat Cell Biol. 2010 Dec; 12(12):1213-9.
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Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancer. Cancer. 2010 Jan 15; 116(2):340-6.