Nuclear Receptor Subfamily 4, Group A, Member 2
"Nuclear Receptor Subfamily 4, Group A, Member 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is found at high levels in BRAIN tissue. The protein is believed to play a role in development and maintenance of NEURONS, particularly dopaminergic neurons.
| Descriptor ID |
D057126
|
| MeSH Number(s) |
D12.776.260.643.415 D12.776.826.209.415
|
| Concept/Terms |
Nuclear Receptor Subfamily 4, Group A, Member 2- Nuclear Receptor Subfamily 4, Group A, Member 2
- Nur-Related Factor 1
- Factor 1, Nur-Related
- Nur Related Factor 1
- Nuclear Receptor-Related Factor 1
- Nuclear Receptor Related Factor 1
- Nurr1 Nuclear Receptor
- Orphan Nuclear Receptor Nurr1
- Nuclear Receptor NR4A2
- NR4A2, Nuclear Receptor
- Receptor NR4A2, Nuclear
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 4, Group A, Member 2".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 4, Group A, Member 2".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in this website by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 4 | 4 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in Profiles.
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Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer. Cell Death Dis. 2025 Nov 03; 16(1):776.
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Dual Targeting of Orphan Nuclear Receptors NR4A1 and NR4A2 for Nonhormonal Endometriosis Therapy. Endocrinology. 2025 Oct 09; 166(11).
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Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1. Structure. 2019 01 02; 27(1):66-77.e5.
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Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease. CNS Neurol Disord Drug Targets. 2012 Sep; 11(6):768-73.
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The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat Cell Biol. 2010 Dec; 12(12):1213-9.
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Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. J Neurosci. 2008 Dec 24; 28(52):14097-106.
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Decreased NURR1 gene expression in patients with Parkinson's disease. J Neurol Sci. 2008 Oct 15; 273(1-2):29-33.
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Loss of RE-1 silencing factor in mesenchymal stem cell-derived dopamine progenitors induces functional maturity. Mol Cell Neurosci. 2008 Oct; 39(2):285-90.
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Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo. Brain Res. 2008 Jul 30; 1222:222-9.
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Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Mol Psychiatry. 2008 Apr; 13(4):417-28.