DAX-1 Orphan Nuclear Receptor
"DAX-1 Orphan Nuclear Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. It is unlike most orphan nuclear receptors in that it appears to lack an essential DNA-binding domain and instead acts as a transcriptional co-repressor. Mutations in the gene Dax-1 cause congenital adrenal hypoplasia.
| Descriptor ID |
D057137
|
| MeSH Number(s) |
D12.776.826.209.059 D12.776.930.780.625.186
|
| Concept/Terms |
DAX-1 Orphan Nuclear Receptor- DAX-1 Orphan Nuclear Receptor
- DAX 1 Orphan Nuclear Receptor
- DSS-AHC Critical Region on the X Chromosome, Gene 1 Protein
- DSS AHC Critical Region on the X Chromosome, Gene 1 Protein
- Nuclear Receptor NR0B1
- Nuclear Receptor DAX-1
- Nuclear Receptor DAX 1
- Nuclear Receptor Subfamily 0, Group B, Member 1
- NR0B1 Protein
- Nuclear Receptor 0B1
|
Below are MeSH descriptors whose meaning is more general than "DAX-1 Orphan Nuclear Receptor".
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This graph shows the total number of publications written about "DAX-1 Orphan Nuclear Receptor" by people in this website by year, and whether "DAX-1 Orphan Nuclear Receptor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "DAX-1 Orphan Nuclear Receptor" by people in Profiles.
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Female-to-male sex reversal associated with unique Xp21.2 deletion disrupting genomic regulatory architecture of the dosage-sensitive sex reversal region. J Med Genet. 2017 10; 54(10):705-709.
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Male-to-female sex reversal associated with an approximately 250 kb deletion upstream of NR0B1 (DAX1). Hum Genet. 2007 Aug; 122(1):63-70.
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Zebrafish dax1 is required for development of the interrenal organ, the adrenal cortex equivalent. Mol Endocrinol. 2006 Nov; 20(11):2630-40.
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Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing. Mol Endocrinol. 2004 Jun; 18(6):1428-37.
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Repressors of androgen and progesterone receptor action. J Biol Chem. 2003 Aug 15; 278(33):31136-48.
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Blockage of the rete testis and efferent ductules by ectopic Sertoli and Leydig cells causes infertility in Dax1-deficient male mice. Endocrinology. 2001 Oct; 142(10):4486-95.
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Ahch, the mouse homologue of DAX1: cloning, characterization and synteny with GyK, the glycerol kinase locus. Gene. 1996 Oct 31; 178(1-2):31-4.