Tumor Suppressor p53-Binding Protein 1
"Tumor Suppressor p53-Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.
| Descriptor ID |
D000071857
|
| MeSH Number(s) |
D12.776.260.805 D12.776.660.235.850 D12.776.664.235.950
|
| Concept/Terms |
Tumor Suppressor p53-Binding Protein 1- Tumor Suppressor p53-Binding Protein 1
- Tumor Suppressor p53 Binding Protein 1
- TP53BP1 Protein
- p202 Protein
- Tumor Protein p53-Binding Protein, 1
- Tumor Protein p53 Binding Protein, 1
- 53BP1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor p53-Binding Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor p53-Binding Protein 1".
This graph shows the total number of publications written about "Tumor Suppressor p53-Binding Protein 1" by people in this website by year, and whether "Tumor Suppressor p53-Binding Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tumor Suppressor p53-Binding Protein 1" by people in Profiles.
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Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells. J Biol Chem. 2022 06; 298(6):101979.
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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function. Cell Rep. 2020 08 11; 32(6):108018.
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PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. 2017 12; 24(12):2013-2021.
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Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons. Sci Rep. 2016 05 11; 6:25705.
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Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015 Nov; 35(21):3633-45.
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Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife. 2013 Oct 29; 2:e01222.
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RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem. 2013 Apr 19; 288(16):11135-43.
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The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1400-7.
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Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Mol Cancer Ther. 2011 Jul; 10(7):1194-206.
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The 53BP1-EXPAND1 connection in chromatin structure regulation. Nucleus. 2010 Nov-Dec; 1(6):472-4.