Proto-Oncogene Proteins c-rel
"Proto-Oncogene Proteins c-rel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.
| Descriptor ID |
D020569
|
| MeSH Number(s) |
D12.776.260.682 D12.776.624.664.700.192 D12.776.660.767 D12.776.930.730
|
| Concept/Terms |
Proto-Oncogene Proteins c-rel- Proto-Oncogene Proteins c-rel
- Proto Oncogene Proteins c rel
- c-rel, Proto-Oncogene Proteins
- p68 c-rel
- c-rel, p68
- p68 c rel
- Proto-Oncogene Protein c-rel
- Proto Oncogene Protein c rel
- c-rel, Proto-Oncogene Protein
- Proto-Oncogene Proteins rel
- Proto Oncogene Proteins rel
- c-rel Protein
- Protein, c-rel
- c rel Protein
- p68(c-rel)
- rel Proto-Oncogene Product p68
- rel Proto Oncogene Product p68
- Proto-Oncogene Products c-rel
- Proto Oncogene Products c rel
- c-rel, Proto-Oncogene Products
- c-rel Proteins
- Proteins, c-rel
- c rel Proteins
- rel Proto-Oncogene Proteins
- Proto-Oncogene Proteins, rel
- rel Proto Oncogene Proteins
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-rel".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-rel".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-rel" by people in this website by year, and whether "Proto-Oncogene Proteins c-rel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-rel" by people in Profiles.
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Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma. Oncotarget. 2015 Sep 15; 6(27):23157-80.
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T cell-intrinsic function of the noncanonical NF-?B pathway in the regulation of GM-CSF expression and experimental autoimmune encephalomyelitis pathogenesis. J Immunol. 2014 Jul 01; 193(1):422-30.
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An integrin ?3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68.
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Irreversible EGFR inhibitor EKB-569 targets low-LET ?-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma. PLoS One. 2011; 6(12):e29705.
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The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol. 2011 Aug 28; 12(10):1002-9.
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BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells. Blood. 2009 May 07; 113(19):4627-36.
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Essential role of C-Rel in nitric-oxide synthase-2 transcriptional activation: time-dependent control by salicylate. Mol Pharmacol. 2006 Dec; 70(6):2004-14.
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A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma. J Clin Endocrinol Metab. 2004 Jul; 89(7):3521-6.
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A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel. J Neurosci. 2004 Apr 21; 24(16):3933-43.
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Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of Rel/NF-kappaB activities. Immunity. 2002 Jan; 16(1):9-21.