Fanconi Anemia Complementation Group D2 Protein
"Fanconi Anemia Complementation Group D2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.
| Descriptor ID |
D052236
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| MeSH Number(s) |
D12.776.313.812 D12.776.660.285 D12.776.744.484
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fanconi Anemia Complementation Group D2 Protein".
Below are MeSH descriptors whose meaning is more specific than "Fanconi Anemia Complementation Group D2 Protein".
This graph shows the total number of publications written about "Fanconi Anemia Complementation Group D2 Protein" by people in this website by year, and whether "Fanconi Anemia Complementation Group D2 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 2 | 3 |
| 2017 | 2 | 1 | 3 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fanconi Anemia Complementation Group D2 Protein" by people in Profiles.
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Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 10; 5(10):eaax6366.
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A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell. 2012 Jul 13; 47(1):61-75.
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Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221). Breast Cancer Res Treat. 2011 Dec; 130(3):993-1002.
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FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science. 2010 Aug 06; 329(5992):693-6.
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Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication. Mol Cell. 2009 Sep 11; 35(5):716-23.
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Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene. 2008 Aug 28; 27(37):5045-56.
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Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem. 2005 Apr 15; 280(15):14877-83.