Fanconi Anemia Complementation Group D2 Protein
"Fanconi Anemia Complementation Group D2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.
| Descriptor ID |
D052236
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| MeSH Number(s) |
D12.776.313.812 D12.776.660.285 D12.776.744.484
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fanconi Anemia Complementation Group D2 Protein".
Below are MeSH descriptors whose meaning is more specific than "Fanconi Anemia Complementation Group D2 Protein".
This graph shows the total number of publications written about "Fanconi Anemia Complementation Group D2 Protein" by people in this website by year, and whether "Fanconi Anemia Complementation Group D2 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 2 | 3 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 3 | 4 |
| 2014 | 1 | 1 | 2 |
| 2016 | 1 | 2 | 3 |
| 2017 | 3 | 2 | 5 |
| 2018 | 3 | 0 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fanconi Anemia Complementation Group D2 Protein" by people in Profiles.
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TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response. Aging (Albany NY). 2020 10 24; 12(20):20268-20284.
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Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 10; 5(10):eaax6366.
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FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R-loops during mild replication stress. FEBS J. 2019 01; 286(1):139-150.
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Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. Pediatr Blood Cancer. 2019 01; 66(1):e27460.
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DNA methylation at the vicinity of the proximal polyadenylation site in FANCD2 gene involves human malignancy. Cell Cycle. 2018; 17(17):2204-2206.
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Constitutive role of the Fanconi anemia D2 gene in the replication stress response. J Biol Chem. 2017 12 08; 292(49):20184-20195.
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FANCD2 and DNA Damage. Int J Mol Sci. 2017 Aug 19; 18(8).
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Involvement of FANCD2 in Energy Metabolism via ATP5a. Sci Rep. 2017 07 07; 7(1):4921.
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Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50. Cancer. 2017 Oct 15; 123(20):3943-3954.
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Activation of the FA pathway mediated by phosphorylation and ubiquitination. Mutat Res. 2017 10; 803-805:89-95.