"Synapsins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
| Descriptor ID |
D016704
|
| MeSH Number(s) |
D12.776.631.750 D12.776.744.840
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Synapsins".
Below are MeSH descriptors whose meaning is more specific than "Synapsins".
This graph shows the total number of publications written about "Synapsins" by people in this website by year, and whether "Synapsins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Synapsins" by people in Profiles.
-
Selective lowering of synapsins induced by oligomeric a-synuclein exacerbates memory deficits. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):E4648-E4657.
-
Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. Diabetes. 2016 08; 65(8):2169-78.
-
Optogenetic assessment of horizontal interactions in primary visual cortex. J Neurosci. 2014 Apr 02; 34(14):4976-90.
-
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PLoS One. 2013; 8(12):e80737.
-
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol. 2004 Oct; 24(20):8872-83.
-
Mitochondrial regulation of synaptic plasticity in the hippocampus. J Biol Chem. 2003 May 16; 278(20):17727-34.
-
Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. J Biol Chem. 1997 Dec 12; 272(50):31235-40.
-
Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6. Genomics. 1995 Jul 20; 28(2):365-6.