"Neurofilament Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
| Descriptor ID |
D016900
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| MeSH Number(s) |
D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Neurofilament Proteins".
Below are MeSH descriptors whose meaning is more specific than "Neurofilament Proteins".
This graph shows the total number of publications written about "Neurofilament Proteins" by people in this website by year, and whether "Neurofilament Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 3 | 3 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2024 | 3 | 1 | 4 |
| 2025 | 2 | 2 | 4 |
| 2026 | 1 | 2 | 3 |
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Below are the most recent publications written about "Neurofilament Proteins" by people in Profiles.
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Plasma Biomarkers of Brain Injury in Critically Ill Children Receiving Extracorporeal Membrane Oxygenation. JAMA Pediatr. 2026 Jun 01; 180(6):639-649.
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Predictive models for ataxia progression and conversion in spinocerebellar ataxia type 1 and 3. Brain. 2026 Apr 07; 149(4):1268-1277.
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Plasma Biomarkers, Brain Volume, and Cognitive Performance in Service Members and Veterans With mTBI: A LIMBIC-CENC Study. JAMA Netw Open. 2026 Feb 02; 9(2):e2559596.
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Blood biomarkers for predicting disability worsening in progressive multiple sclerosis: a multinational, individual participant-level analysis. J Neurol Neurosurg Psychiatry. 2025 Oct 15; 96(11):1046-1052.
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Prevalence, Severity, and Progression of Cerebellar Cognitive-Affective Syndrome in Patients With Spinocerebellar Ataxias. Neurology. 2025 Sep 09; 105(5):e213980.
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ApoE e4-dependent Alteration of CXCR3?+?CD127+ CD4+ T cells associates with elevated plasma neurofilament light chain in Alzheimer's disease. J Alzheimers Dis. 2025 Apr; 104(3):792-807.
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Distinct plasma lipids predict axonal injury and multiple sclerosis activity. J Neurol Neurosurg Psychiatry. 2025 Jan 16; 96(2):150-157.
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Serum Neurofilament Light-Chain Levels in Essential Tremor: A Replication Study. Neurodegener Dis. 2024; 24(3-4):141-147.
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Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis. Nat Commun. 2024 May 20; 15(1):4297.
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Temporal Profile of Serum Neurofilament Light (NF-L) and Heavy (pNF-H) Level Associations With 6-Month Cognitive Performance in Patients With Moderate-Severe Traumatic Brain Injury. J Head Trauma Rehabil. 2024 Nov-Dec 01; 39(6):E470-E480.