"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
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| MeSH Number(s) |
A08.637.400 A11.650.400
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 3 | 3 |
| 2014 | 2 | 1 | 3 |
| 2015 | 3 | 1 | 4 |
| 2016 | 2 | 3 | 5 |
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 3 | 5 |
| 2020 | 6 | 6 | 12 |
| 2021 | 4 | 1 | 5 |
| 2022 | 3 | 2 | 5 |
| 2023 | 3 | 3 | 6 |
| 2024 | 2 | 3 | 5 |
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Below are the most recent publications written about "Microglia" by people in Profiles.
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CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy. Metab Brain Dis. 2024 Dec 10; 40(1):57.
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Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. Neuro Oncol. 2024 Dec 05; 26(12):2239-2255.
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Remyelination protects neurons from DLK-mediated neurodegeneration. Nat Commun. 2024 Oct 23; 15(1):9148.
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Dual targeting macrophages and microglia is a therapeutic vulnerability in models of PTEN-deficient glioblastoma. J Clin Invest. 2024 Oct 01; 134(22).
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The microglial P2Y6 receptor as a therapeutic target for neurodegenerative diseases. Transl Neurodegener. 2024 Sep 07; 13(1):47.
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Glioblastoma Phagocytic Cell Death: Balancing the Opportunities for Therapeutic Manipulation. Cells. 2024 05 11; 13(10).
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Spatially Resolved Microglia/Macrophages in Recurrent Glioblastomas Overexpress Fatty Acid Metabolism and Phagocytic Genes. Curr Oncol. 2024 02 23; 31(3):1183-1194.
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P2Y6 Receptor-Dependent Microglial Phagocytosis of Synapses during Development Regulates Synapse Density and Memory. J Neurosci. 2023 11 29; 43(48):8090-8103.
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TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nat Neurosci. 2024 Jan; 27(1):48-62.
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iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2024 02; 72(2):452-469.