"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Descriptor ID |
D017628
|
MeSH Number(s) |
A08.637.400 A11.650.400
|
Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
2000 | 1 | 0 | 1 |
2001 | 1 | 1 | 2 |
2002 | 1 | 0 | 1 |
2003 | 0 | 2 | 2 |
2004 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2007 | 2 | 1 | 3 |
2008 | 0 | 3 | 3 |
2009 | 4 | 2 | 6 |
2010 | 5 | 2 | 7 |
2011 | 2 | 1 | 3 |
2012 | 4 | 4 | 8 |
2013 | 2 | 4 | 6 |
2014 | 4 | 1 | 5 |
2015 | 4 | 1 | 5 |
2016 | 4 | 5 | 9 |
2017 | 1 | 2 | 3 |
2018 | 2 | 3 | 5 |
2019 | 3 | 4 | 7 |
2020 | 9 | 8 | 17 |
2021 | 6 | 2 | 8 |
2022 | 2 | 3 | 5 |
2023 | 2 | 3 | 5 |
To return to the timeline,
click here.
Below are the most recent publications written about "Microglia" by people in Profiles.
-
TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nat Neurosci. 2024 Jan; 27(1):48-62.
-
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis. Cell Rep. 2023 10 31; 42(10):113240.
-
Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates A? pathology in a mouse model of Alzheimer's disease. Mol Neurodegener. 2023 08 15; 18(1):56.
-
TMEM106B regulates microglial proliferation and survival in response to demyelination. Sci Adv. 2023 05 05; 9(18):eadd2676.
-
Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy. J Clin Invest. 2023 01 03; 133(1).
-
Microglia and astrocyte activation is region-dependent in the a-synuclein mouse model of Parkinson's disease. Glia. 2023 Mar; 71(3):571-587.
-
Ablation of Siglec-E augments brain inflammation and ischemic injury. J Neuroinflammation. 2022 Jul 20; 19(1):191.
-
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid ? plaques. Immunity. 2022 05 10; 55(5):879-894.e6.
-
Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation. Bioorg Med Chem. 2022 03 15; 58:116645.
-
HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity. Theranostics. 2022; 12(2):603-619.