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MELANIE SAMUEL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology
    DivisionOphthalmology

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


    Collapse Research 
    Collapse research activities and funding
    R01EY035254     (SAMUEL, MELANIE A)Sep 1, 2023 - Jan 31, 2027
    NIH
    Microglial plasticity mechanisms in the developing retina
    Role: Principal Investigator
    R01EY033772     (SAMUEL, MELANIE A)Feb 1, 2023 - Jan 31, 2026
    NIH
    Molecular specification of dopaminergic neuron diversity
    Role: Principal Investigator
    R01EY032566     (SAMUEL, MELANIE A)Sep 30, 2022 - Jun 30, 2027
    NIH
    Dopamine Mediated Control of Retinal Vascular Integrity
    Role: Principal Investigator
    R21AG074163     (SAMUEL, MELANIE A)May 15, 2022 - Apr 30, 2024
    NIH
    Diversity Supplement (Qudrat Abdulwahab) for Role of pericyte nanotubes in age-related neurovascular dysfunction
    Role: Principal Investigator
    R01EY030458     (SAMUEL, MELANIE A)Sep 1, 2019 - Jun 30, 2025
    NIH
    Molecular Basis of Outer Retina Development and Repair
    Role: Principal Investigator
    R56AG061808     (SAMUEL, MELANIE A)Aug 15, 2019 - Jul 31, 2021
    NIH
    Synaptic decline in retina as a predictor of Alzheimer's disease
    Role: Principal Investigator
    DP2EY027984     (SAMUEL, MELANIE A)Sep 30, 2016 - Sep 29, 2021
    NIH
    Synaptic Reprogramming of Adult Neurons
    Role: Principal Investigator
    R00AG044444     (SAMUEL, MELANIE A)Apr 1, 2015 - Jan 31, 2019
    NIH
    Molecular Mechanisms of Age-related Synaptic Disorganization
    Role: Principal Investigator
    K99AG044444     (SAMUEL, MELANIE A)Sep 1, 2013 - May 31, 2015
    NIH
    Molecular Mechanisms of Age-related Synaptic Disorganization
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang KC, Tawfik M, Samuel MA. Retinal ganglion cell circuits and glial interactions in humans and mice. Trends Neurosci. 2024 Oct 24. PMID: 39455342.
      Citations:    Fields:    
    2. Liang JH, Akhanov V, Ho A, Tawfik M, D'Souza SP, Cameron MA, Lang RA, Samuel MA. Dopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina. Curr Biol. 2023 09 25; 33(18):3821-3834.e5. PMID: 37572663; PMCID: PMC10529464.
      Citations: 1     Fields:    Translation:Cells
    3. Zhu JD, Tarachand SP, Abdulwahab Q, Samuel MA. Structure, Function, and Molecular Landscapes of the Aging Retina. Annu Rev Vis Sci. 2023 09 15; 9:177-199. PMID: 37196423; PMCID: PMC10524587.
      Citations: 2     Fields:    Translation:Cells
    4. Jiang D, Burger CA, Akhanov V, Liang JH, Mackin RD, Albrecht NE, Andrade P, Schafer DP, Samuel MA. Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina. Immunity. 2022 12 13; 55(12):2318-2335.e7. PMID: 36379210; PMCID: PMC9772037.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Cao Y, Fajardo D, Guerrero-Given D, Samuel MA, Ohtsuka T, Boye SE, Kamasawa N, Martemyanov KA. Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Curr Biol. 2022 11 21; 32(22):4783-4796.e3. PMID: 36179691; PMCID: PMC9691582.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Liang JH, Alevy J, Akhanov V, Seo R, Massey CA, Jiang D, Zhou J, Sillitoe RV, Noebels JL, Samuel MA. Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects. Dis Model Mech. 2022 09 01; 15(9). PMID: 35972048; PMCID: PMC9509889.
      Citations:    
    7. Albrecht NE, Jiang D, Akhanov V, Hobson R, Speer CM, Robichaux MA, Samuel MA. Rapid 3D-STORM imaging of diverse molecular targets in tissue. Cell Rep Methods. 2022 07 18; 2(7):100253. PMID: 35880013; PMCID: PMC9308169.
      Citations:    
    8. D'Souza SP, Swygart DI, Wienbar SR, Upton BA, Zhang KX, Mackin RD, Casasent AK, Samuel MA, Schwartz GW, Lang RA. Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells. J Comp Neurol. 2022 06; 530(8):1247-1262. PMID: 34743323; PMCID: PMC8969148.
      Citations:    Fields:    Translation:AnimalsCells
    9. Burger CA, Jiang D, Mackin RD, Samuel MA. Development and maintenance of vision's first synapse. Dev Biol. 2021 08; 476:218-239. PMID: 33848537; PMCID: PMC8559589.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Burger CA, Albrecht NE, Jiang D, Liang JH, Samuel MA, Poch? RA. LKB1 and AMPK instruct cone nuclear position to modify visual function. Cell Rep. 2021 02 02; 34(5):108698. PMID: 33535040; PMCID: PMC7906279.
      Citations: 1     Fields:    Translation:AnimalsCells
    11. Burger CA, Jiang D, Li F, Samuel MA. C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina. Front Neural Circuits. 2020; 14:583391. PMID: 33177995; PMCID: PMC7596380.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Burger CA, Alevy J, Casasent AK, Jiang D, Albrecht NE, Liang JH, Hirano AA, Brecha NC, Samuel MA. LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina. Elife. 2020 05 07; 9. PMID: 32378514; PMCID: PMC7237215.
      Citations: 3     Fields:    Translation:AnimalsCells
    13. Li F, Jiang D, Samuel MA. Microglia in the developing retina. Neural Dev. 2019 12 30; 14(1):12. PMID: 31888774; PMCID: PMC6938006.
      Citations: 24     Fields:    Translation:AnimalsCells
    14. Jiang D, Burger CA, Casasent AK, Albrecht NE, Li F, Samuel MA. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. J Comp Neurol. 2020 04 01; 528(5):729-755. PMID: 31609468; PMCID: PMC7147688.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Greer PL, Samuel MA. Becoming a Principal Investigator: Designing and Navigating Your Academic Adventure. Neuron. 2019 09 25; 103(6):959-963. PMID: 31557459.
      Citations:    Fields:    Translation:Humans
    16. Alevy J, Burger CA, Albrecht NE, Jiang D, Samuel MA. Progressive myoclonic epilepsy-associated gene Kctd7 regulates retinal neurovascular patterning and function. Neurochem Int. 2019 10; 129:104486. PMID: 31175897; PMCID: PMC6702070.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A, Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL, Dickinson ME, Samuel MA. Rapid and Integrative Discovery of Retina Regulatory Molecules. Cell Rep. 2018 08 28; 24(9):2506-2519. PMID: 30157441; PMCID: PMC6170014.
      Citations: 8     Fields:    Translation:HumansCells
    18. Sarin S, Zuniga-Sanchez E, Kurmangaliyev YZ, Cousins H, Patel M, Hernandez J, Zhang KX, Samuel MA, Morey M, Sanes JR, Zipursky SL. Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In?Vivo Somatic CRISPR Mutagenesis. Neuron. 2018 04 04; 98(1):109-126.e8. PMID: 29576390; PMCID: PMC5930001.
      Citations: 27     Fields:    Translation:AnimalsCells
    19. Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR, Foretz M, Viollet B. LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep; 17(9):1190-7. PMID: 25086610; PMCID: PMC5369022.
      Citations: 47     Fields:    Translation:AnimalsCells
    20. Hussmann KL, Samuel MA, Kim KS, Diamond MS, Fredericksen BL. Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes. J Virol. 2013 Mar; 87(5):2814-22. PMID: 23269784; PMCID: PMC3571364.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    21. Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR. Agrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One. 2012; 7(10):e46663. PMID: 23056392; PMCID: PMC3463559.
      Citations: 61     Fields:    Translation:AnimalsCells
    22. Samuel MA, Zhang Y, Meister M, Sanes JR. Age-related alterations in neurons of the mouse retina. J Neurosci. 2011 Nov 02; 31(44):16033-44. PMID: 22049445; PMCID: PMC3238393.
      Citations: 71     Fields:    Translation:AnimalsCells
    23. Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb 12; 6(2):e1000764. PMID: 20169186; PMCID: PMC2820531.
      Citations: 141     Fields:    Translation:AnimalsCells
    24. Szretter KJ, Samuel MA, Gilfillan S, Fuchs A, Colonna M, Diamond MS. The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol. 2009 Sep; 83(18):9329-38. PMID: 19587044; PMCID: PMC2738257.
      Citations: 78     Fields:    Translation:AnimalsCells
    25. Diamond MS, Mehlhop E, Oliphant T, Samuel MA. The host immunologic response to West Nile encephalitis virus. Front Biosci (Landmark Ed). 2009 01 01; 14(8):3024-34. PMID: 19273254.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    26. Daffis S, Samuel MA, Suthar MS, Gale M, Diamond MS. Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol. 2008 Nov; 82(21):10349-58. PMID: 18715906; PMCID: PMC2573187.
      Citations: 184     Fields:    Translation:AnimalsCells
    27. Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M, Diamond MS. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol. 2008 Sep; 82(17):8465-75. PMID: 18562536; PMCID: PMC2519659.
      Citations: 102     Fields:    Translation:AnimalsCells
    28. Samuel MA, Wang H, Siddharthan V, Morrey JD, Diamond MS. Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17140-5. PMID: 17939996; PMCID: PMC2040476.
      Citations: 99     Fields:    Translation:AnimalsCells
    29. Noueiry AO, Olivo PD, Slomczynska U, Zhou Y, Buscher B, Geiss B, Engle M, Roth RM, Chung KM, Samuel M, Diamond MS. Identification of novel small-molecule inhibitors of West Nile virus infection. J Virol. 2007 Nov; 81(21):11992-2004. PMID: 17715228; PMCID: PMC2168801.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    30. Daffis S, Samuel MA, Keller BC, Gale M, Diamond MS. Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms. PLoS Pathog. 2007 Jul 27; 3(7):e106. PMID: 17676997; PMCID: PMC1933455.
      Citations: 121     Fields:    Translation:AnimalsCells
    31. Samuel MA, Morrey JD, Diamond MS. Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. J Virol. 2007 Mar; 81(6):2614-23. PMID: 17192305; PMCID: PMC1866006.
      Citations: 95     Fields:    Translation:AnimalsCells
    32. Samuel MA, Diamond MS. Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol. 2006 Oct; 80(19):9349-60. PMID: 16973541; PMCID: PMC1617273.
      Citations: 172     Fields:    Translation:HumansAnimalsCells
    33. Keller BC, Fredericksen BL, Samuel MA, Mock RE, Mason PW, Diamond MS, Gale M. Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. J Virol. 2006 Oct; 80(19):9424-34. PMID: 16973548; PMCID: PMC1617238.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    34. Samuel MA, Whitby K, Keller BC, Marri A, Barchet W, Williams BR, Silverman RH, Gale M, Diamond MS. PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol. 2006 Jul; 80(14):7009-19. PMID: 16809306; PMCID: PMC1489062.
      Citations: 155     Fields:    Translation:AnimalsCells
    35. Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol. 2006 Jun; 80(11):5338-48. PMID: 16699014; PMCID: PMC1472130.
      Citations: 104     Fields:    Translation:AnimalsCells
    36. Rosenke K, Samuel MA, McDowell ET, Toerne MA, Fortunato EA. An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection. Virology. 2006 Apr 25; 348(1):19-34. PMID: 16455125.
      Citations: 21     Fields:    Translation:HumansCells
    37. Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J. 2006 Jan 15; 393(Pt 2):503-11. PMID: 16229682; PMCID: PMC1360700.
      Citations: 43     Fields:    Translation:AnimalsCells
    38. Shrestha B, Samuel MA, Diamond MS. CD8+ T cells require perforin to clear West Nile virus from infected neurons. J Virol. 2006 Jan; 80(1):119-29. PMID: 16352536; PMCID: PMC1317548.
      Citations: 124     Fields:    Translation:AnimalsCells
    39. Pepin KM, Samuel MA, Wichman HA. Variable pleiotropic effects from mutations at the same locus hamper prediction of fitness from a fitness component. Genetics. 2006 Apr; 172(4):2047-56. PMID: 16361237; PMCID: PMC1456406.
      Citations: 18     Fields:    Translation:Cells
    40. Samuel MA, Diamond MS. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol. 2005 Nov; 79(21):13350-61. PMID: 16227257; PMCID: PMC1262587.
      Citations: 240     Fields:    Translation:AnimalsCells
    41. Klein RS, Lin E, Zhang B, Luster AD, Tollett J, Samuel MA, Engle M, Diamond MS. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol. 2005 Sep; 79(17):11457-66. PMID: 16103196; PMCID: PMC1193600.
      Citations: 229     Fields:    Translation:AnimalsCells
    42. Pierson TC, Diamond MS, Ahmed AA, Valentine LE, Davis CW, Samuel MA, Hanna SL, Puffer BA, Doms RW. An infectious West Nile virus that expresses a GFP reporter gene. Virology. 2005 Mar 30; 334(1):28-40. PMID: 15749120.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
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