"Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
| Descriptor ID |
D012701
|
| MeSH Number(s) |
D02.092.211.215.801.852 D03.633.100.473.914.814 D23.469.050.650
|
| Concept/Terms |
Serotonin- Serotonin
- 5-Hydroxytryptamine
- 5 Hydroxytryptamine
- Hippophaine
- 3-(2-Aminoethyl)-1H-indol-5-ol
- Enteramine
- 5-HT
|
Below are MeSH descriptors whose meaning is more general than "Serotonin".
Below are MeSH descriptors whose meaning is more specific than "Serotonin".
This graph shows the total number of publications written about "Serotonin" by people in this website by year, and whether "Serotonin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 3 | 5 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 5 | 5 |
| 1999 | 1 | 3 | 4 |
| 2000 | 1 | 2 | 3 |
| 2001 | 0 | 1 | 1 |
| 2002 | 2 | 3 | 5 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 3 | 4 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 2 | 3 |
| 2008 | 2 | 0 | 2 |
| 2009 | 3 | 2 | 5 |
| 2010 | 3 | 1 | 4 |
| 2011 | 1 | 2 | 3 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 3 | 4 |
| 2016 | 2 | 3 | 5 |
| 2018 | 0 | 2 | 2 |
| 2019 | 2 | 3 | 5 |
| 2020 | 2 | 3 | 5 |
| 2021 | 4 | 5 | 9 |
| 2022 | 2 | 8 | 10 |
| 2023 | 1 | 2 | 3 |
| 2024 | 4 | 5 | 9 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Serotonin" by people in Profiles.
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Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation. Metabolism. 2025 02; 163:156099.
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Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans. Sci Adv. 2024 06 28; 10(26):eadl2675.
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Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice. Transl Psychiatry. 2024 02 27; 14(1):122.
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Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. Nat Med. 2022 12; 28(12):2537-2546.
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Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. 2022 Oct 05; 110(19):3154-3167.e7.
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Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles. Cells. 2022 08 08; 11(15).
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A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nat Neurosci. 2022 05; 25(5):646-658.
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Gai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell Rep. 2021 11 16; 37(7):109997.
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5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding. Mol Psychiatry. 2021 12; 26(12):7211-7224.
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Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nat Commun. 2021 06 10; 12(1):3525.