"Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
| Descriptor ID |
D012701
|
| MeSH Number(s) |
D02.092.211.215.801.852 D03.633.100.473.914.814 D23.469.050.650
|
| Concept/Terms |
Serotonin- Serotonin
- 5-Hydroxytryptamine
- 5 Hydroxytryptamine
- Hippophaine
- 3-(2-Aminoethyl)-1H-indol-5-ol
- Enteramine
- 5-HT
|
Below are MeSH descriptors whose meaning is more general than "Serotonin".
Below are MeSH descriptors whose meaning is more specific than "Serotonin".
This graph shows the total number of publications written about "Serotonin" by people in this website by year, and whether "Serotonin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 6 | 3 | 9 |
| 1996 | 3 | 4 | 7 |
| 1997 | 1 | 1 | 2 |
| 1998 | 0 | 5 | 5 |
| 1999 | 1 | 4 | 5 |
| 2000 | 1 | 3 | 4 |
| 2001 | 0 | 2 | 2 |
| 2002 | 2 | 3 | 5 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 4 | 5 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 3 | 4 |
| 2008 | 2 | 0 | 2 |
| 2009 | 3 | 2 | 5 |
| 2010 | 3 | 1 | 4 |
| 2011 | 1 | 2 | 3 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 2 | 4 |
| 2016 | 2 | 3 | 5 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 2 | 4 |
| 2020 | 1 | 2 | 3 |
| 2021 | 4 | 5 | 9 |
| 2022 | 1 | 7 | 8 |
| 2023 | 1 | 2 | 3 |
| 2024 | 3 | 3 | 6 |
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Below are the most recent publications written about "Serotonin" by people in Profiles.
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Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood. Gastroenterology. 2025 Apr; 168(4):754-768.
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Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation. Metabolism. 2025 Feb; 163:156099.
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Mouse enteric neurons control intestinal plasmacytoid dendritic cell function via serotonin-HTR7 signaling. Nat Commun. 2024 Oct 25; 15(1):9237.
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Histone serotonylation regulates ependymoma tumorigenesis. Nature. 2024 Aug; 632(8026):903-910.
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Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans. Sci Adv. 2024 Jun 28; 10(26):eadl2675.
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Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice. Transl Psychiatry. 2024 Feb 27; 14(1):122.
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Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation. J Clin Invest. 2023 11 01; 133(21).
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Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT2C Receptor and Dual 5-HT2C/5-HT2A Receptor Modulators. J Med Chem. 2023 07 27; 66(14):9992-10009.
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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 06 16; 380(6650):eade0027.
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Survey-Based Analysis of the Clinical Treatment Status of Irritable Bowel Syndrome in Korea. J Korean Med Sci. 2023 Apr 24; 38(16):e126.