Receptor, Serotonin, 5-HT2C
"Receptor, Serotonin, 5-HT2C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serotonin receptor subtype found primarily in the CENTRAL NERVOUS SYSTEM and the CHOROID PLEXUS. This receptor subtype is believed to mediate the anorectic action of SEROTONIN, while selective antagonists of the 5-HT2C receptor appear to induce ANXIETY. Several isoforms of this receptor subtype exist, due to adenine deaminase editing of the receptor mRNA.
| Descriptor ID |
D044405
|
| MeSH Number(s) |
D12.776.543.750.670.800.200.200 D12.776.543.750.695.800.200.200 D12.776.543.750.720.850.200.200
|
| Concept/Terms |
Receptor, Serotonin, 5-HT2C- Receptor, Serotonin, 5-HT2C
- 5-HT2C Receptor
- 5 HT2C Receptor
- Receptor, 5-HT2C
- 5-Hydroxytryptamine Type 2C Receptor
- 5 Hydroxytryptamine Type 2C Receptor
- Receptor, 5-Hydroxytryptamine Type 2C
- Receptor, 5 Hydroxytryptamine Type 2C
- Serotonin 2C Receptor
- Receptor, Serotonin 2C
- 5-HT(2C) Receptor
- 5-Hydroxytryptamine Type 2C Receptors
- 5 Hydroxytryptamine Type 2C Receptors
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Serotonin, 5-HT2C".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Biogenic Amine [D12.776.543.750.670]
- Receptors, Serotonin [D12.776.543.750.670.800]
- Receptors, Serotonin, 5-HT2 [D12.776.543.750.670.800.200]
- Receptor, Serotonin, 5-HT2C [D12.776.543.750.670.800.200.200]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Serotonin [D12.776.543.750.695.800]
- Receptors, Serotonin, 5-HT2 [D12.776.543.750.695.800.200]
- Receptor, Serotonin, 5-HT2C [D12.776.543.750.695.800.200.200]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Serotonin [D12.776.543.750.720.850]
- Receptors, Serotonin, 5-HT2 [D12.776.543.750.720.850.200]
- Receptor, Serotonin, 5-HT2C [D12.776.543.750.720.850.200.200]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Serotonin, 5-HT2C".
This graph shows the total number of publications written about "Receptor, Serotonin, 5-HT2C" by people in this website by year, and whether "Receptor, Serotonin, 5-HT2C" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2019 | 1 | 1 | 2 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2024 | 2 | 0 | 2 |
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click here.
Below are the most recent publications written about "Receptor, Serotonin, 5-HT2C" by people in Profiles.
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Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans. Sci Adv. 2024 Jun 28; 10(26):eadl2675.
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Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function. Endocrinology. 2024 May 27; 165(7).
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Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT2C Receptor and Dual 5-HT2C/5-HT2A Receptor Modulators. J Med Chem. 2023 07 27; 66(14):9992-10009.
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Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. Nat Med. 2022 12; 28(12):2537-2546.
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Gai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell Rep. 2021 11 16; 37(7):109997.
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Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss. J Neurosci. 2021 06 30; 41(26):5734-5746.
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Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro. Sci Rep. 2019 11 13; 9(1):16737.
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Inverse agonists of the 5-HT2A receptor reduce nicotine withdrawal signs in rats. Neurosci Lett. 2019 11 20; 713:134524.
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Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. PLoS One. 2018; 13(8):e0203137.
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Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biol Psychiatry. 2017 05 01; 81(9):737-747.