"Agouti-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted protein of approximately 131 amino acids that is related to AGOUTI SIGNALING PROTEIN and is also an antagonist of MELANOCORTIN RECEPTOR activity. It is expressed primarily in the HYPOTHALAMUS and the ADRENAL GLAND. As a paracrine signaling molecule, AGRP is known to regulate food intake and body weight. Elevated AGRP has been associated with OBESITY.
| Descriptor ID |
D054369
|
| MeSH Number(s) |
D12.644.276.074 D12.776.467.074 D23.529.074
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Agouti-Related Protein".
Below are MeSH descriptors whose meaning is more specific than "Agouti-Related Protein".
This graph shows the total number of publications written about "Agouti-Related Protein" by people in this website by year, and whether "Agouti-Related Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 4 | 5 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 4 | 4 |
| 2025 | 1 | 0 | 1 |
| 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Agouti-Related Protein" by people in Profiles.
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Sex-specific differences in mediobasal hypothalamus in response to nutritional states. Nat Commun. 2026 Feb 19; 17(1).
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Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice. Nat Metab. 2025 Oct; 7(10):2004-2017.
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Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons. Sci Adv. 2023 02 22; 9(8):eabq6718.
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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. Nat Metab. 2023 01; 5(1):147-164.
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Protein tyrosine phosphatase receptor d serves as the orexigenic asprosin receptor. Cell Metab. 2022 04 05; 34(4):549-563.e8.
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Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nat Commun. 2021 06 10; 12(1):3525.
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A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia. Nat Commun. 2021 05 11; 12(1):2662.
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AgRP neurons trigger long-term potentiation and facilitate food seeking. Transl Psychiatry. 2021 01 05; 11(1):11.
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Profound and redundant functions of arcuate neurons in obesity development. Nat Metab. 2020 08; 2(8):763-774.
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Heparin Increases Food Intake through AgRP Neurons. Cell Rep. 2017 Sep 05; 20(10):2455-2467.