"Apelin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.
| Descriptor ID |
D000073861
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| MeSH Number(s) |
D12.644.276.150 D23.529.134
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apelin".
Below are MeSH descriptors whose meaning is more specific than "Apelin".
This graph shows the total number of publications written about "Apelin" by people in this website by year, and whether "Apelin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apelin" by people in Profiles.
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Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017 Aug 29; 20(9):2116-2130.
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Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett. 2017 02 01; 386:179-188.
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Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun. 2015 Jan 19; 6:6020.