"Hedgehog Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intercellular signaling proteins that play an important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.
| Descriptor ID |
D053823
|
| MeSH Number(s) |
D12.644.276.671 D12.776.467.671 D23.529.671
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hedgehog Proteins".
Below are MeSH descriptors whose meaning is more specific than "Hedgehog Proteins".
This graph shows the total number of publications written about "Hedgehog Proteins" by people in this website by year, and whether "Hedgehog Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 6 | 6 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 4 | 4 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 7 | 7 |
| 2004 | 0 | 6 | 6 |
| 2005 | 0 | 9 | 9 |
| 2006 | 5 | 12 | 17 |
| 2007 | 10 | 4 | 14 |
| 2008 | 5 | 7 | 12 |
| 2009 | 12 | 4 | 16 |
| 2010 | 7 | 6 | 13 |
| 2011 | 15 | 10 | 25 |
| 2012 | 11 | 4 | 15 |
| 2013 | 3 | 5 | 8 |
| 2014 | 12 | 6 | 18 |
| 2015 | 8 | 4 | 12 |
| 2016 | 4 | 6 | 10 |
| 2017 | 3 | 7 | 10 |
| 2018 | 4 | 5 | 9 |
| 2019 | 5 | 3 | 8 |
| 2020 | 1 | 4 | 5 |
| 2021 | 3 | 4 | 7 |
| 2022 | 3 | 8 | 11 |
| 2023 | 1 | 6 | 7 |
| 2024 | 2 | 2 | 4 |
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Below are the most recent publications written about "Hedgehog Proteins" by people in Profiles.
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Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development. Development. 2024 Oct 01; 151(19).
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REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma. Sci Rep. 2024 06 12; 14(1):13596.
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Identification of an early survival prognostic gene signature for localized osteosarcoma patients. Sci Rep. 2024 03 27; 14(1):7327.
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Treatments on the horizon for locally advanced basal cell carcinoma. Cancer Lett. 2024 May 01; 589:216821.
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Final analysis of phase II results with cemiplimab in metastatic basal cell carcinoma after hedgehog pathway inhibitors. Ann Oncol. 2024 Feb; 35(2):221-228.
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Pax3 lineage-specific deletion of Gpr161 is associated with spinal neural tube and craniofacial malformations during embryonic development. Dis Model Mech. 2023 Nov 01; 16(11).
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Phase 2 open-label, multicenter, single-arm study of cemiplimab in patients with locally advanced basal cell carcinoma after hedgehog inhibitor therapy: Extended follow-up. J Am Acad Dermatol. 2024 Feb; 90(2):414-418.
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Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas. Nat Commun. 2023 10 07; 14(1):6279.
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Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis. Int J Mol Sci. 2023 Jul 12; 24(14).
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TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system. Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4):e2209964120.