"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
| Descriptor ID |
D016203
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.500.250 D08.811.913.696.620.682.700.646.500.984.500 D12.644.360.250.067.249 D12.644.360.250.580.500 D12.776.167.200.067.249 D12.776.167.200.580.500 D12.776.476.250.067.249 D12.776.476.250.580.500 D12.776.744.360
|
| Concept/Terms |
CDC2 Protein Kinase- CDC2 Protein Kinase
- Protein Kinase, CDC2
- Cdk1 Protein Kinase
- Protein Kinase, Cdk1
- cdk1 Kinase
- cdc2+ Protein
- Cyclin-Dependent Kinase 1
- Cyclin Dependent Kinase 1
p34cdc2 Protein- p34cdc2 Protein
- Protein p34cdc2
- p34cdc2, Protein
- Histone Kinase p34(cdc2)
|
Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".
Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".
This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in this website by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 |
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2011 | 2 | 2 | 4 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.
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Low-Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer. Cancer Res. 2024 Nov 15; 84(22):3864-3880.
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Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 10 01; 33(12):ar115.
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ATR Inhibition Induces CDK1-SPOP Signaling and Enhances Anti-PD-L1 Cytotoxicity in Prostate Cancer. Clin Cancer Res. 2021 09 01; 27(17):4898-4909.
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Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma. Cancer Res. 2019 10 01; 79(19):5088-5101.
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Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Cell. 2018 03 22; 173(1):104-116.e12.
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Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer. Oncogene. 2018 04; 37(17):2251-2269.
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Phenotypic and molecular characterisation of CDK13-related congenital heart defects, dysmorphic facial features and intellectual developmental disorders. Genome Med. 2017 08 14; 9(1):73.
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Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2. Mol Cancer Ther. 2016 11; 15(11):2758-2766.
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Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics. Mol Cell Proteomics. 2016 07; 15(7):2448-61.
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Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress. Int J Radiat Oncol Biol Phys. 2016 06 01; 95(2):782-90.