Cyclin-Dependent Kinase 9
"Cyclin-Dependent Kinase 9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DIFFERENTIATION, and APOPTOSIS. It is found associated with CYCLIN T and is a component of POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B.
| Descriptor ID |
D042863
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| MeSH Number(s) |
D08.811.641.752 D08.811.913.696.620.682.700.646.500.500.750 D12.644.360.250.067.900 D12.776.167.200.067.900 D12.776.476.250.067.900 D12.776.930.955.500.500
|
| Concept/Terms |
Cyclin-Dependent Kinase 9- Cyclin-Dependent Kinase 9
- Cyclin Dependent Kinase 9
- PITALRE Kinase
- Cdk9 Protein Kinase
- CDK9 Kinase
- Cdc2-related Kinase PITALRE
- Cdc2 related Kinase PITALRE
- Kinase PITALRE, Cdc2-related
- PITALRE, Cdc2-related Kinase
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 9".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 9".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 9" by people in this website by year, and whether "Cyclin-Dependent Kinase 9" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 2 | 0 | 2 |
| 2012 | 3 | 1 | 4 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 2 | 3 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 9" by people in Profiles.
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Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep. 2016 07 05; 6:29090.
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Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik. Mol Cell Biol. 2014 Sep 15; 34(18):3435-49.
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Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol. 2010 Jun 20; 28(18):3015-22.
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Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther. 2009 Feb; 8(2):441-8.
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Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop. J Biol Chem. 2008 Nov 28; 283(48):33578-84.
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MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein. J Biomed Sci. 2002 May-Jun; 9(3):234-45.
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P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. J Biol Chem. 2002 May 10; 277(19):16873-8.
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Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol Cell Biol. 2002 Jan; 22(1):321-31.