Cyclin-Dependent Kinase 5
"Cyclin-Dependent Kinase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CELL DEATH of NERVE CELLS. It is closely related to other CYCLIN-DEPENDENT KINASES but does not seem to participate in CELL CYCLE regulation.
| Descriptor ID |
D051360
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.500.500 D12.644.360.250.067.875 D12.776.167.200.067.875 D12.776.476.250.067.875
|
| Concept/Terms |
Cyclin-Dependent Kinase 5- Cyclin-Dependent Kinase 5
- Cyclin Dependent Kinase 5
- Neuronal Cdc2-Like Protein Kinase
- Neuronal Cdc2 Like Protein Kinase
- Cdk5 Protein Kinase
- Protein Kinase, Cdk5
- Cdk5 Protein
- PSSALRE Protein
- Cdc2-Related Kinase PSSALRE
- Cdc2 Related Kinase PSSALRE
- PSSALRE, Cdc2-Related Kinase
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 5".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 5".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 5" by people in this website by year, and whether "Cyclin-Dependent Kinase 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 1 | 3 |
| 2011 | 2 | 1 | 3 |
| 2013 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 5" by people in Profiles.
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Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition. Nat Cell Biol. 2024 Oct; 26(10):1773-1789.
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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Cell Rep. 2023 04 25; 42(4):112316.
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Development of CDK2 and CDK5 Dual Degrader TMX-2172. Angew Chem Int Ed Engl. 2020 08 10; 59(33):13865-13870.
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PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2019 11 15; 25(22):6839-6851.
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CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. PLoS One. 2015; 10(7):e0131833.
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Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis. Oncotarget. 2015 May 20; 6(14):12080-93.
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Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models. Mol Cancer Ther. 2015 Jul; 14(7):1532-9.
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Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Mol Cell Proteomics. 2014 Nov; 13(11):2986-3000.
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Talin1 phosphorylation activates ?1 integrins: a novel mechanism to promote prostate cancer bone metastasis. Oncogene. 2015 Apr 02; 34(14):1811-21.
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Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem. 2013 Jul 26; 288(30):22042-56.