"CDC2-CDC28 Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE; S CEREVISIAE; and the CDC2 PROTEIN KINASE found in mammalian species.
| Descriptor ID |
D042846
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.500 D12.644.360.250.067 D12.776.167.200.067 D12.776.476.250.067
|
| Concept/Terms |
CDC2-CDC28 Kinases- CDC2-CDC28 Kinases
- CDC2 CDC28 Kinases
- CDC2+-CDC28-related Protein Kinase
- CDC2+ CDC28 related Protein Kinase
|
Below are MeSH descriptors whose meaning is more general than "CDC2-CDC28 Kinases".
Below are MeSH descriptors whose meaning is more specific than "CDC2-CDC28 Kinases".
This graph shows the total number of publications written about "CDC2-CDC28 Kinases" by people in this website by year, and whether "CDC2-CDC28 Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 6 | 0 | 6 |
| 1995 | 2 | 2 | 4 |
| 1996 | 6 | 0 | 6 |
| 1997 | 3 | 0 | 3 |
| 1998 | 6 | 0 | 6 |
| 1999 | 6 | 0 | 6 |
| 2000 | 6 | 0 | 6 |
| 2001 | 7 | 0 | 7 |
| 2002 | 6 | 0 | 6 |
| 2003 | 6 | 3 | 9 |
| 2004 | 2 | 8 | 10 |
| 2005 | 2 | 5 | 7 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "CDC2-CDC28 Kinases" by people in Profiles.
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The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma. Mod Pathol. 2021 02; 34(2):327-335.
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Additional-structural-chromosomal aberrations are associated with inferior clinical outcome in patients with hyperdiploid multiple myeloma: a single-institution experience. Mod Pathol. 2017 06; 30(6):843-853.
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Outcome of Patients with Multiple Myeloma and CKS1B Gene Amplification after Autologous Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 12; 22(12):2159-2164.
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Differential expression of CKS-1B in typical and blastoid variants of mantle cell lymphoma. Hum Pathol. 2010 Oct; 41(10):1448-55.
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Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. Int J Cancer. 2008 Aug 01; 123(3):543-51.
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CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. Blood. 2007 Jun 01; 109(11):4995-5001.
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Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells. FEBS Lett. 2005 Jul 18; 579(18):3932-40.
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HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition. Mol Cell Biol. 2005 Jul; 25(14):6140-53.
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Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005 Apr 21; 24(18):2929-43.
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A role for PML3 in centrosome duplication and genome stability. Mol Cell. 2005 Mar 04; 17(5):721-32.