Maturation-Promoting Factor
"Maturation-Promoting Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
| Descriptor ID |
D016200
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.984 D12.644.360.250.580 D12.776.167.200.580 D12.776.476.250.580
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| Concept/Terms |
Maturation-Promoting Factor- Maturation-Promoting Factor
- Maturation Promoting Factor
- Histone H1 Kinase, M-Phase-Specific
- Histone H1 Kinase, M Phase Specific
- Mitosis-Promoting Factor
- Mitosis Promoting Factor
- Histone H1 Kinase, Growth-Associated
- Histone H1 Kinase, Growth Associated
- M Phase-Promoting Factor
- M Phase Promoting Factor
|
Below are MeSH descriptors whose meaning is more general than "Maturation-Promoting Factor".
Below are MeSH descriptors whose meaning is more specific than "Maturation-Promoting Factor".
This graph shows the total number of publications written about "Maturation-Promoting Factor" by people in this website by year, and whether "Maturation-Promoting Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Maturation-Promoting Factor" by people in Profiles.
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ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G49-G65.
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Time-related effect of GnRH on histone H1 kinase activity in the goldfish follicle-enclosed oocyte. Can J Physiol Pharmacol. 2000 Dec; 78(12):1067-71.
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Direct action of GnRH variants on goldfish oocyte meiosis and follicular steroidogenesis. Mol Cell Endocrinol. 2000 Feb 25; 160(1-2):75-88.
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The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7965-70.
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Mos and the cell cycle. Prog Cell Cycle Res. 1997; 3:251-9.
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Ca2+ is involved through type II calmodulin-dependent protein kinase in cyclin degradation and exit from metaphase. Biochim Biophys Acta. 1994 Sep 29; 1223(3):325-32.
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cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor. Mol Biol Cell. 1994 Feb; 5(2):135-45.
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Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs. Nature. 1993 Nov 18; 366(6452):270-3.
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Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans. J Cell Biol. 1993 May; 121(3):621-30.
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Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system. J Biol Chem. 1992 Oct 05; 267(28):20346-51.