Cyclin-Dependent Kinase 8
"Cyclin-Dependent Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.
| Descriptor ID |
D056850
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| MeSH Number(s) |
D05.500.374.500 D08.811.913.696.620.682.700.646.500.968 D12.644.360.024.309.500 D12.644.360.250.547 D12.776.157.057.072.500 D12.776.167.200.548 D12.776.476.024.388.500 D12.776.476.250.548 D12.776.660.551.500
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| Concept/Terms |
Cyclin-Dependent Kinase 8- Cyclin-Dependent Kinase 8
- Cyclin Dependent Kinase 8
- Cdk8 Cyclin-Dependent Kinase
- Cdk8 Cyclin Dependent Kinase
- Cyclin-Dependent Kinase, Cdk8
- Kinase, Cdk8 Cyclin-Dependent
- Cdk8 Protein Kinase
- Kinase, Cdk8 Protein
- Protein Kinase, Cdk8
- Cell Division Protein Kinase 8
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 8".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 8".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 8" by people in this website by year, and whether "Cyclin-Dependent Kinase 8" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 8" by people in Profiles.
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Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila. Nat Commun. 2024 Apr 18; 15(1):3326.
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De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy. Am J Hum Genet. 2020 05 07; 106(5):717-725.
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De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder. Hum Genet. 2018 May; 137(5):375-388.
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H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-?-Catenin Signaling in Colorectal Cancer. EBioMedicine. 2016 Nov; 13:113-124.
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Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov; 16(11):1080-91.
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Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression. Retrovirology. 2012 Jun 22; 9:52.
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The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8. Virology. 2011 Jan 20; 409(2):299-307.
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Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. Mol Cell Biol. 1998 Jul; 18(7):4291-300.