Mediator Complex Subunit 1
"Mediator Complex Subunit 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mediator complex subunit that is believed to play a key role in the coactivation of nuclear receptor-activated transcription by the mediator complex. It interacts with a variety of nuclear receptors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; VITAMIN D RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; ESTROGEN RECEPTORS; and GLUCOCORTICOID RECEPTORS.
| Descriptor ID |
D056913
|
| MeSH Number(s) |
D05.500.374.750 D12.644.360.024.309.750 D12.644.360.024.314.049 D12.776.157.057.072.750 D12.776.157.057.080.049 D12.776.476.024.388.750 D12.776.476.024.394.049 D12.776.660.551.750 D12.776.660.675.049 D12.776.930.617.049
|
| Concept/Terms |
Mediator Complex Subunit 1- Mediator Complex Subunit 1
- TRAP220
- Mediator of RNA Polymerase II Transcription Subunit 1
- p53 Regulatory Protein RB18A
- RB18A
- Vitamin D Receptor-Interacting Protein Complex Component DRIP205
- Vitamin D Receptor Interacting Protein Complex Component DRIP205
- Peroxisome Proliferator-Activated Receptor Binding Protein
- Peroxisome Proliferator Activated Receptor Binding Protein
- PPAR-Binding Protein
- PPAR Binding Protein
- Thyroid Receptor Interacting Protein 2
- TR-Associated Protein P220
- TR Associated Protein P220
- TRIP2 (Thyroid Receptor Interacting Protein 2)
- DRIP205
- Thyroid Hormone Receptor Associated Protein 220
|
Below are MeSH descriptors whose meaning is more general than "Mediator Complex Subunit 1".
Below are MeSH descriptors whose meaning is more specific than "Mediator Complex Subunit 1".
This graph shows the total number of publications written about "Mediator Complex Subunit 1" by people in this website by year, and whether "Mediator Complex Subunit 1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Mediator Complex Subunit 1" by people in Profiles.
-
ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity. Mol Cancer Res. 2013 Jul; 11(7):736-47.
-
Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol Cell Biol. 2003 Jun; 23(11):3763-73.
-
TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol. 2002 Aug; 22(15):5626-37.
-
The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2642-7.
-
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell. 1999 Mar; 3(3):361-70.