Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
| Descriptor ID |
D000071248
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| MeSH Number(s) |
D12.644.360.024.314.650 D12.776.157.057.080.650 D12.776.157.725.813.875 D12.776.476.024.394.650 D12.776.660.675.650 D12.776.664.962.813.875 D12.776.930.617.650
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
Below are MeSH descriptors whose meaning is more specific than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
This graph shows the total number of publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in this website by year, and whether "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 6 | 6 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 2 | 4 |
| 2017 | 1 | 3 | 4 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 2 | 3 |
| 2022 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in Profiles.
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Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway. Dev Cell. 2024 May 06; 59(9):1175-1191.e7.
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PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models. BMC Med. 2023 02 01; 21(1):38.
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PGC1a/? Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer. Cancer Res. 2022 04 01; 82(7):1423-1434.
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Regulation of PGC1a Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant a1-Antitrypsin Deficiency Variant Z. Gastroenterology. 2022 07; 163(1):270-284.
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High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease. Nutrients. 2021 Nov 23; 13(12).
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Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions. Brief Bioinform. 2021 11 05; 22(6).
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PGC1a is required for the renoprotective effect of lncRNA Tug1 in?vivo and links Tug1 with urea cycle metabolites. Cell Rep. 2021 08 10; 36(6):109510.
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Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. PLoS One. 2019; 14(7):e0218111.
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ERR1 and PGC1a associated mitochondrial alterations correlate with pan-cancer disparity in African Americans. J Clin Invest. 2019 03 28; 129(6):2351-2356.
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Age-dependent cardiac function during experimental sepsis: effect of pharmacological activation of AMP-activated protein kinase by AICAR. Am J Physiol Heart Circ Physiol. 2018 10 01; 315(4):H826-H837.