"CELF Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of RRM proteins which contain two N-terminal RNA RECOGNITION MOTIF (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 amino acids between the second and third RRM domains. They regulate pre-mRNA ALTERNATIVE SPLICING and also function in RNA EDITING and PROTEIN BIOSYNTHESIS.
| Descriptor ID |
D000067878
|
| MeSH Number(s) |
D12.776.157.725.813.250 D12.776.664.962.813.250
|
| Concept/Terms |
CELF Proteins- CELF Proteins
- Proteins, CELF
- BRUNOL Proteins
- Proteins, BRUNOL
- CUGBP, Elav-Like Family Member Proteins
- CUGBP, Elav Like Family Member Proteins
- CUG Triplet Repeat, RNA-Binding Proteins
- CUG Triplet Repeat, RNA Binding Proteins
- CUG-BP Proteins
- CUG BP Proteins
- Proteins, CUG-BP
- CUGBP Proteins
- Proteins, CUGBP
- Bruno-Like Family Member Proteins
- Bruno Like Family Member Proteins
|
Below are MeSH descriptors whose meaning is more general than "CELF Proteins".
Below are MeSH descriptors whose meaning is more specific than "CELF Proteins".
This graph shows the total number of publications written about "CELF Proteins" by people in this website by year, and whether "CELF Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "CELF Proteins" by people in Profiles.
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CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study. J Clin Oncol. 2016 Mar 10; 34(8):863-70.
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Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Res. 2015 Jun; 25(6):858-71.
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A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20333-8.
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Cardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy. Mol Cell Biol. 2005 Jul; 25(14):6267-78.
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Identification of CELF splicing activation and repression domains in vivo. Nucleic Acids Res. 2005; 33(9):2769-80.
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Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment. Mol Cell Biol. 2005 Feb; 25(3):879-87.
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ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. Nucleic Acids Res. 2004; 32(3):1232-41.
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CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. J Biol Chem. 2004 Apr 23; 279(17):17756-64.
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Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell. 2002 Mar; 9(3):649-58.
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The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol. 2001 Feb; 21(4):1285-96.