"CELF1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the CELF PROTEINS family which binds GU rich elements (GREs) and CUG-triplet repeats in the 3'UTR of mammalian mRNA transcripts that undergo rapid turnover. It also binds AU-rich elements (AREs or EDEN-like) in the 3'UTR of JUN and FOS mRNAs. Mutations in the human CELF1 gene are associated with MYOTONIC DYSTROPHY type 1.
| Descriptor ID |
D000067879
|
| MeSH Number(s) |
D12.776.157.725.813.250.500 D12.776.664.962.813.250.500
|
| Concept/Terms |
CELF1 Protein- CELF1 Protein
- Protein, CELF1
- Bruno-Like 2 Protein
- 2 Protein, Bruno-Like
- Bruno Like 2 Protein
- Protein, Bruno-Like 2
- CUGBP, Elav-Like Family Member 1 Protein
- CUGBP, Elav Like Family Member 1 Protein
- CUGBP1 Protein
- Protein, CUGBP1
- BRUNOL2 Protein
- Protein, BRUNOL2
- CUG Triplet Repeat, RNA-Binding Protein 1
- CUG Triplet Repeat, RNA Binding Protein 1
|
Below are MeSH descriptors whose meaning is more general than "CELF1 Protein".
Below are MeSH descriptors whose meaning is more specific than "CELF1 Protein".
This graph shows the total number of publications written about "CELF1 Protein" by people in this website by year, and whether "CELF1 Protein" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 3 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 2 | 4 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "CELF1 Protein" by people in Profiles.
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PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells. J Biol Chem. 2024 Nov; 300(11):107826.
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Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting. Hum Mol Genet. 2020 06 27; 29(10):1729-1744.
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Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1. Hum Mol Genet. 2018 08 15; 27(16):2789-2804.
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CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT. Nat Commun. 2016 11 21; 7:13362.
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Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1. Sci Rep. 2016 10 19; 6:35550.
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miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9551-6.
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Roles for RNA-binding proteins in development and disease. Brain Res. 2016 09 15; 1647:1-8.
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p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways. Mol Cell Biol. 2015 Sep 01; 35(17):3005-16.
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Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Res. 2015 Jun; 25(6):858-71.
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Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nat Commun. 2014 Apr 22; 5:3603.