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THOMAS COOPER

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
Houston, TX 77030
Email
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Integrative Physiology
    DivisionMolecular Physiology & Biophysics

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Collapse Biography 
    Collapse awards and honors
    1981 - 1982NIH Medical Research Trainee predoctoral award, University of California, San Francisco
    1982 - 1985NIH NRSA Postdoctoral Fellowship, University of California, San Francisco
    1985 - 1986Bank of America Giannini Foundation Postdoctoral Award, University of California, San Francisco
    1991 - 1994March of Dimes Basil O'Connor Starter Scholar Research Award, Baylor College of Medicine
    1992 - 1997Established Investigator Award, American Heart Association, Baylor College of Medicine
    1998Michael E. DeBakey, M.D. Excellence in Research Award, Baylor College of Medicine
    2003S. Donald Greenberg Endowed Chair, Baylor College of Medicine
    2014Michael E. DeBakey, M.D. Excellence in Research Award, Baylor College of Medicine
    2015R. Clarence and Irene H. Fulbright Endowed Chair, Baylor College of Medicine

    Collapse Overview 
    Collapse overview
    See our lab webpage: https://www.bcm.edu/research/labs/tom-cooper/?PMID=14453
    The realization that most human genes generate multiple mRNAs encoding different protein isoforms and variable untranslated regions via alternative splicing and alternative polyadenylation has revealed an extensive degree of regulation that remains to be explored.

    The Cooper Lab is interested in understanding the mechanisms of this regulation, from how RNA binding proteins regulate splicing of individual pre-mRNAs to the signaling events that coordinate RNA processing networks during development.

    A second major interest in the lab is the pathogenic mechanism of myotonic dystrophy in which disruption of developmentally regulated RNA processing causes primary features of the disease. Mechanistic understanding of myotonic dystrophy has led to development of therapeutic approaches being testing using mouse models established in the lab.

    Collapse Research 
    Collapse research activities and funding
    R01AR082852     (COOPER, THOMAS A)Sep 6, 2023 - Aug 31, 2028
    NIH
    Mechanisms of Skeletal Muscle Pathogenesis in Myotonic Dystrophy Type 1
    Role: Principal Investigator
    R01HL147020     (COOPER, THOMAS A)Apr 15, 2019 - Mar 31, 2024
    NIH
    Pathogenic mechanisms and therapeutics for the cardiac manifestations of myotonic dystrophy type 1
    Role: Principal Investigator
    R01AR060733     (COOPER, THOMAS A)Apr 1, 2011 - Feb 29, 2024
    NIH
    Transcriptome processing networks in skeletal muscle: mechanisms and functions
    Role: Principal Investigator
    RC2HG005624     (BURGE, CHRISTOPHER B)Sep 30, 2009 - Aug 31, 2012
    NIH
    Deep Sequencing Analysis of mRNA Isoform Expression Changes in Myotonic Dystrophy
    Role: Co-Principal Investigator
    R01GM076493     (COOPER, THOMAS A)Feb 1, 2006 - Jul 31, 2011
    NIH
    Mechanisms of Developmentally Regulated Splicing
    Role: Principal Investigator
    R01AR045653     (COOPER, THOMAS A)Feb 8, 1999 - Aug 31, 2021
    NIH
    Molecular Pathogenesis of Myotonic Dystrophy
    Role: Principal Investigator
    R01HL045565     (COOPER, THOMAS A)Jul 1, 1991 - Nov 30, 2019
    NIH
    Troponin T Alternative Splicing in Embryonic Heart
    Role: Principal Investigator
    R29HL045565     (COOPER, THOMAS ALEXANDER)Jan 1, 1991 - Jul 16, 1996
    NIH
    TROPONIN T ALTERNATIVE SPLICING IN EMBRYONIC HEART
    Role: Principal Investigator
    T32GM008231     (NELSON, DAVID LOREN)Jul 1, 1990 - Jun 30, 2020
    NIH
    Training Program in Cell and Molecular Biology
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Penna MS, Hu RC, Rodney GG, Cooper TA. The role of Limch1 alternative splicing in skeletal muscle function. Life Sci Alliance. 2023 06; 6(6). PMID: 36977593; PMCID: PMC10052820.
      Citations:    Fields:    Translation:AnimalsCells
    2. Nitschke L, Hu RC, Miller AN, Lucas L, Cooper TA. Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function. Nucleic Acids Res. 2023 02 22; 51(3):1245-1259. PMID: 36617982; PMCID: PMC9943662.
      Citations:    Fields:    Translation:AnimalsCells
    3. Lucas L, Cooper TA. Insights into Cell-Specific Functions of Microtubules in Skeletal Muscle Development and Homeostasis. Int J Mol Sci. 2023 Feb 02; 24(3). PMID: 36769228; PMCID: PMC9917663.
      Citations: 1     Fields:    Translation:HumansCells
    4. Peterson JAM, Cooper TA. Clinical and Molecular Insights into Gastrointestinal Dysfunction in Myotonic Dystrophy Types 1 & 2. Int J Mol Sci. 2022 Nov 26; 23(23). PMID: 36499107; PMCID: PMC9737721.
      Citations:    Fields:    Translation:HumansCells
    5. Johnson SJ, Cooper TA. Overlapping mechanisms of lncRNA and expanded microsatellite RNA. Wiley Interdiscip Rev RNA. 2021 01; 12(1):e1634. PMID: 33191580; PMCID: PMC7880542.
      Citations: 2     Fields:    Translation:Cells
    6. Cox DC, Guan X, Xia Z, Cooper TA. Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting. Hum Mol Genet. 2020 06 27; 29(10):1729-1744. PMID: 32412585; PMCID: PMC7322576.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. Sharp L, Cox DC, Cooper TA. Endurance exercise leads to beneficial molecular and physiological effects in a mouse model of myotonic dystrophy type 1. Muscle Nerve. 2019 12; 60(6):779-789. PMID: 31509256; PMCID: PMC7026901.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Payer LM, Steranka JP, Ardeljan D, Fitzgerald KC, Calabresi PA, Cooper TA, Burns KH, Walker J. Alu insertion variants alter mRNA splicing. Nucleic Acids Res. 2019 01 10; 47(1):421-431. PMID: 30418605; PMCID: PMC6326789.
      Citations: 27     Fields:    Translation:HumansCells
    9. Blue RE, Koushik A, Engels NM, Wiedner HJ, Cooper TA, Giudice J. Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology. Int J Biochem Cell Biol. 2018 12; 105:134-143. PMID: 30316870; PMCID: PMC6289647.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Pang PD, Alsina KM, Cao S, Koushik AB, Wehrens XHT, Cooper TA. CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. J Am Heart Assoc. 2018 10 02; 7(19):e010393. PMID: 30371314; PMCID: PMC6404881.
      Citations: 9     Fields:    Translation:AnimalsCells
    11. Morriss GR, Rajapakshe K, Huang S, Coarfa C, Cooper TA. Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1. Hum Mol Genet. 2018 08 15; 27(16):2789-2804. PMID: 29771332; PMCID: PMC6077786.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    12. Singh RK, Kolonin AM, Fiorotto ML, Cooper TA. Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis. Cell Rep. 2018 07 03; 24(1):197-208. PMID: 29972780; PMCID: PMC6070147.
      Citations: 21     Fields:    Translation:AnimalsCells
    13. Rao AN, Cooper TA. A Therapeutic Double Whammy: Transcriptional or Post-transcriptional Suppression of Microsatellite Repeat Toxicity by Cas9. Mol Cell. 2017 11 02; 68(3):473-475. PMID: 29100050.
      Citations:    Fields:    Translation:AnimalsCells
    14. Brinegar AE, Xia Z, Loehr JA, Li W, Rodney GG, Cooper TA. Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 08 11; 6. PMID: 28826478; PMCID: PMC5577920.
      Citations: 28     Fields:    Translation:AnimalsCells
    15. Sharpe JJ, Cooper TA. Unexpected consequences: exon skipping caused by CRISPR-generated mutations. Genome Biol. 2017 06 14; 18(1):109. PMID: 28615035; PMCID: PMC5470267.
      Citations: 31     Fields:    
    16. Morriss GR, Cooper TA. Protein sequestration as a normal function of long noncoding RNAs and a pathogenic mechanism of RNAs containing nucleotide repeat expansions. Hum Genet. 2017 09; 136(9):1247-1263. PMID: 28484853; PMCID: PMC5677592.
      Citations: 13     Fields:    Translation:HumansCells
    17. Manning KS, Cooper TA. The roles of RNA processing in translating genotype to phenotype. Nat Rev Mol Cell Biol. 2017 02; 18(2):102-114. PMID: 27847391; PMCID: PMC5544131.
      Citations: 78     Fields:    Translation:HumansCells
    18. Giudice J, Loehr JA, Rodney GG, Cooper TA. Alternative Splicing of Four Trafficking Genes Regulates Myofiber Structure and Skeletal Muscle Physiology. Cell Rep. 2016 11 15; 17(8):1923-1933. PMID: 27851958; PMCID: PMC5140099.
      Citations: 17     Fields:    Translation:AnimalsCells
    19. Giudice J, Xia Z, Li W, Cooper TA. Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1. Sci Rep. 2016 10 19; 6:35550. PMID: 27759042; PMCID: PMC5069560.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Cox DC, Cooper TA. Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements. Mol Cell. 2016 04 21; 62(2):155-156. PMID: 27105111.
      Citations: 1     Fields:    Translation:Humans
    21. Brinegar AE, Cooper TA. Roles for RNA-binding proteins in development and disease. Brain Res. 2016 09 15; 1647:1-8. PMID: 26972534; PMCID: PMC5003702.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    22. Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF, Dominguez-Vida?a R. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8. PMID: 26331541; PMCID: PMC4831063.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    23. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ. Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol. 2015 Jul; 13(7):e1002197. PMID: 26176594; PMCID: PMC4503542.
      Citations: 24     Fields:    Translation:AnimalsCells
    24. Wang ET, Ward AJ, Cherone JM, Giudice J, Wang TT, Treacy DJ, Lambert NJ, Freese P, Saxena T, COOPER TA, Burge CB. \Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Res. 2015; 25(6):858-71.
    25. Wang ET, Ward AJ, Cherone JM, Giudice J, Wang TT, Treacy DJ, Lambert NJ, Freese P, Saxena T, Cooper TA, Burge CB. Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Res. 2015 Jun; 25(6):858-71. PMID: 25883322; PMCID: PMC4448682.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    26. Gennarino VA, Singh RK, White JJ, De Maio A, Han K, Kim JY, Jafar-Nejad P, di Ronza A, Kang H, Sayegh LS, Cooper TA, Sillitoe RV, Zoghbi HY, Orr HT. Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell. 2015 Mar 12; 160(6):1087-98. PMID: 25768905; PMCID: PMC4383046.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    27. Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, Li W. Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. Nat Commun. 2014 Nov 20; 5:5274. PMID: 25409906; PMCID: PMC4467577.
      Citations: 208     Fields:    Translation:HumansCells
    28. Singh RK, Xia Z, Bland CS, Kalsotra A, Scavuzzo MA, Curk T, Ule J, Li W, Cooper TA. Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis. Mol Cell. 2014 Aug 21; 55(4):592-603. PMID: 25087874; PMCID: PMC4142074.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    29. Pedrotti S, Cooper TA. In Brief: (mis)splicing in disease. J Pathol. 2014 May; 233(1):1-3. PMID: 24615176; PMCID: PMC4300095.
      Citations: 4     Fields:    Translation:HumansCells
    30. Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA. Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nat Commun. 2014 Apr 22; 5:3603. PMID: 24752171; PMCID: PMC4018662.
      Citations: 76     Fields:    Translation:AnimalsCells
    31. Kalsotra A, Singh RK, Gurha P, Ward AJ, Creighton CJ, Cooper TA. The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression. Cell Rep. 2014 Jan 30; 6(2):336-45. PMID: 24412363; PMCID: PMC3927417.
      Citations: 52     Fields:    Translation:HumansAnimals
    32. Giudice J, Cooper TA. RNA-binding proteins in heart development. Adv Exp Med Biol. 2014; 825:389-429. PMID: 25201112.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    33. Echeverria GV, COOPER TA. Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron. Nucleic Acids Res. 2014; 42(3):1893-903.
    34. Echeverria GV, Cooper TA. Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron. Nucleic Acids Res. 2014 Feb; 42(3):1893-903. PMID: 24185704; PMCID: PMC3919616.
      Citations: 20     Fields:    Translation:HumansCells
    35. Gao Z, Cooper TA. Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13570-5. PMID: 23901116; PMCID: PMC3746907.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    36. Gao Z, Cooper TA. Antisense oligonucleotides: rising stars in eliminating RNA toxicity in myotonic dystrophy. Hum Gene Ther. 2013 May; 24(5):499-507. PMID: 23252746; PMCID: PMC3655630.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    37. Cooper TA. Implications of widespread covalent modification of mRNA. Circ Res. 2012 Dec 07; 111(12):1491-3. PMID: 23223930.
      Citations: 2     Fields:    
    38. Singh RK, Cooper TA. Pre-mRNA splicing in disease and therapeutics. Trends Mol Med. 2012 Aug; 18(8):472-82. PMID: 22819011; PMCID: PMC3411911.
      Citations: 208     Fields:    Translation:HumansAnimalsCells
    39. Lee JE, Bennett CF, Cooper TA. RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4221-6. PMID: 22371589; PMCID: PMC3306674.
      Citations: 77     Fields:    Translation:AnimalsCells
    40. Echeverria GV, Cooper TA. RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity. Brain Res. 2012 Jun 26; 1462:100-11. PMID: 22405728; PMCID: PMC3372679.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    41. Kalsotra A, Cooper TA. Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet. 2011 Sep 16; 12(10):715-29. PMID: 21921927; PMCID: PMC3321218.
      Citations: 327     Fields:    Translation:HumansAnimalsCells
    42. Orengo JP, Ward AJ, Cooper TA. Alternative splicing dysregulation secondary to skeletal muscle regeneration. Ann Neurol. 2011 Apr; 69(4):681-90. PMID: 21400563; PMCID: PMC3082633.
      Citations: 42     Fields:    Translation:AnimalsCells
    43. Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3665-70. PMID: 21307310; PMCID: PMC3048138.
      Citations: 356     Fields:    Translation:HumansAnimalsCells
    44. Grammatikakis I, Goo YH, Echeverria GV, Cooper TA. Identification of MBNL1 and MBNL3 domains required for splicing activation and repression. Nucleic Acids Res. 2011 Apr; 39(7):2769-80. PMID: 21109529; PMCID: PMC3074124.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    45. Bland CS, Wang ET, Vu A, David MP, Castle JC, Johnson JM, Burge CB, Cooper TA. Global regulation of alternative splicing during myogenic differentiation. Nucleic Acids Res. 2010 Nov; 38(21):7651-64. PMID: 20634200; PMCID: PMC2995044.
      Citations: 92     Fields:    Translation:AnimalsCells
    46. Ward AJ, Rimer M, Killian JM, Dowling JJ, Cooper TA. CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Hum Mol Genet. 2010 Sep 15; 19(18):3614-22. PMID: 20603324; PMCID: PMC2928132.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    47. Kalsotra A, Wang K, Li PF, Cooper TA. MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development. Genes Dev. 2010 Apr 01; 24(7):653-8. PMID: 20299448; PMCID: PMC2849122.
      Citations: 66     Fields:    Translation:AnimalsCells
    48. Koshelev M, Sarma S, Price RE, Wehrens XH, Cooper TA. Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15; 19(6):1066-75. PMID: 20051426; PMCID: PMC2830830.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    49. Ward AJ, Cooper TA. The pathobiology of splicing. J Pathol. 2010 Jan; 220(2):152-63. PMID: 19918805; PMCID: PMC2855871.
      Citations: 175     Fields:    Translation:HumansCells
    50. Lee JE, Cooper TA. Pathogenic mechanisms of myotonic dystrophy. Biochem Soc Trans. 2009 Dec; 37(Pt 6):1281-6. PMID: 19909263; PMCID: PMC3873089.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    51. Wang GS, Kuyumcu-Martinez MN, Sarma S, Mathur N, Wehrens XH, Cooper TA. PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest. 2009 Dec; 119(12):3797-806. PMID: 19907076; PMCID: PMC2786786.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    52. Cooper TA. Chemical reversal of the RNA gain of function in myotonic dystrophy. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18433-4. PMID: 19864622; PMCID: PMC2774032.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    53. Cooper TA. Molecular biology. Neutralizing toxic RNA. Science. 2009 Jul 17; 325(5938):272-3. PMID: 19608901.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    54. Goo YH, Cooper TA. CUGBP2 directly interacts with U2 17S snRNP components and promotes U2 snRNA binding to cardiac troponin T pre-mRNA. Nucleic Acids Res. 2009 Jul; 37(13):4275-86. PMID: 19443441; PMCID: PMC2715230.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    55. Cooper TA, Wan L, Dreyfuss G. RNA and disease. Cell. 2009 Feb 20; 136(4):777-93. PMID: 19239895; PMCID: PMC2866189.
      Citations: 551     Fields:    Translation:Cells
    56. Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20333-8. PMID: 19075228; PMCID: PMC2629332.
      Citations: 271     Fields:    Translation:AnimalsCells
    57. Orengo JP, Chambon P, Metzger D, Mosier DR, Snipes GJ, Cooper TA. Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2646-51. PMID: 18272483; PMCID: PMC2268190.
      Citations: 96     Fields:    Translation:AnimalsCells
    58. Dhaenens CM, Schraen-Maschke S, Tran H, Vingtdeux V, Ghanem D, Leroy O, Delplanque J, Vanbrussel E, Delacourte A, Vermersch P, Maurage CA, Gruffat H, Sergeant A, Mahadevan MS, Ishiura S, Cooper TA, Caillet-Boudin ML, Charlet-Berguerand N, Sergeant N, Bu?e L, Sablonni?re B. Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats. Exp Neurol. 2008 Apr; 210(2):467-78. PMID: 18177861.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    59. Kuyumcu-Martinez NM, Wang GS, Cooper TA. Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation. Mol Cell. 2007 Oct 12; 28(1):68-78. PMID: 17936705; PMCID: PMC2083558.
      Citations: 241     Fields:    Translation:HumansAnimalsCells
    60. Wang GS, Kearney DL, De Biasi M, Taffet G, Cooper TA. Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy. J Clin Invest. 2007 Oct; 117(10):2802-11. PMID: 17823658; PMCID: PMC1964514.
      Citations: 106     Fields:    Translation:AnimalsCells
    61. Wang GS, Cooper TA. Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet. 2007 Oct; 8(10):749-61. PMID: 17726481.
      Citations: 459     Fields:    Translation:HumansCells
    62. Bland CS, Cooper TA. Micromanaging alternative splicing during muscle differentiation. Dev Cell. 2007 Feb; 12(2):171-2. PMID: 17276332.
      Citations: 5     Fields:    Translation:AnimalsCells
    63. Orengo JP, Cooper TA. Alternative splicing in disease. Adv Exp Med Biol. 2007; 623:212-23. PMID: 18380349.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    64. Orengo JP, Bundman D, Cooper TA. A bichromatic fluorescent reporter for cell-based screens of alternative splicing. Nucleic Acids Res. 2006; 34(22):e148. PMID: 17142220; PMCID: PMC1669726.
      Citations: 47     Fields:    Translation:AnimalsCells
    65. Cooper TA. A reversal of misfortune for myotonic dystrophy? N Engl J Med. 2006 Oct 26; 355(17):1825-7. PMID: 17065646.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    66. Singh G, Cooper TA. Minigene reporter for identification and analysis of cis elements and trans factors affecting pre-mRNA splicing. Biotechniques. 2006 Aug; 41(2):177-81. PMID: 16925019.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    67. Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, Ashizawa T, Cooper TA, Botas J, de Haro M, Faustino NA. MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Hum Mol Genet. 2006 Jul 01; 15(13):2138-45. PMID: 16723374.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    68. Kuyumcu-Martinez NM, Cooper TA. Misregulation of alternative splicing causes pathogenesis in myotonic dystrophy. Prog Mol Subcell Biol. 2006; 44:133-59. PMID: 17076268; PMCID: PMC4127983.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    69. Cooper TA. Use of minigene systems to dissect alternative splicing elements. Methods. 2005 Dec; 37(4):331-40. PMID: 16314262.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    70. Ladd AN, Taffet G, Hartley C, Kearney DL, Cooper TA. Cardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy. Mol Cell Biol. 2005 Jul; 25(14):6267-78. PMID: 15988035; PMCID: PMC1168813.
      Citations: 42     Fields:    Translation:AnimalsCells
    71. Ladd AN, Stenberg MG, Swanson MS, Cooper TA. Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. Dev Dyn. 2005 Jul; 233(3):783-93. PMID: 15830352.
      Citations: 67     Fields:    Translation:AnimalsCells
    72. Ho TH, Savkur RS, Poulos MG, Mancini MA, Swanson MS, Cooper TA. Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy. J Cell Sci. 2005 Jul 01; 118(Pt 13):2923-33. PMID: 15961406.
      Citations: 99     Fields:    Translation:HumansCells
    73. Han J, Cooper TA. Identification of CELF splicing activation and repression domains in vivo. Nucleic Acids Res. 2005; 33(9):2769-80. PMID: 15894795; PMCID: PMC1126903.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    74. Ho TH, Bundman D, Armstrong DL, Cooper TA. Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy. Hum Mol Genet. 2005 Jun 01; 14(11):1539-47. PMID: 15843400.
      Citations: 117     Fields:    Translation:AnimalsCells
    75. Cooper TA, Faustino NA. Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment. Mol Cell Biol. 2005 Feb; 25(3):879-87. PMID: 15657417; PMCID: PMC544011.
      Citations: 61     Fields:    Translation:HumansCells
    76. Cooper TA. Alternative splicing regulation impacts heart development. Cell. 2005 Jan 14; 120(1):1-2. PMID: 15652472.
      Citations: 16     Fields:    Translation:HumansCells
    77. Ho TH, Charlet-B N, Poulos MG, Singh G, Swanson MS, Cooper TA. Muscleblind proteins regulate alternative splicing. EMBO J. 2004 Aug 04; 23(15):3103-12. PMID: 15257297; PMCID: PMC514918.
      Citations: 249     Fields:    Translation:HumansAnimalsCells
    78. Ladd AN, Cooper TA. Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events. J Cell Sci. 2004 Jul 15; 117(Pt 16):3519-29. PMID: 15226369.
      Citations: 25     Fields:    Translation:AnimalsCells
    79. Savkur RS, Philips AV, Cooper TA, Dalton JC, Moseley ML, Ranum LP, Day JW. Insulin receptor splicing alteration in myotonic dystrophy type 2. Am J Hum Genet. 2004 Jun; 74(6):1309-13. PMID: 15114529; PMCID: PMC1182097.
      Citations: 70     Fields:    Translation:HumansCells
    80. Singh G, Charlet-B N, Han J, Cooper TA. ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. Nucleic Acids Res. 2004; 32(3):1232-41. PMID: 14973222; PMCID: PMC373409.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    81. Ladd AN, Nguyen NH, Malhotra K, Cooper TA. CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. J Biol Chem. 2004 Apr 23; 279(17):17756-64. PMID: 14761971.
      Citations: 43     Fields:    Translation:HumansCells
    82. Cooper TA, Faustino NA. Pre-mRNA splicing and human disease. Genes Dev. 2003 Feb 15; 17(4):419-37. PMID: 12600935.
      Citations: 522     Fields:    Translation:Cells
    83. Charlet-B N, Savkur RS, Singh G, Philips AV, Grice EA, Cooper TA. Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol Cell. 2002 Jul; 10(1):45-53. PMID: 12150906.
      Citations: 259     Fields:    Translation:HumansCells
    84. Charlet-B N, Logan P, Singh G, Cooper TA. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell. 2002 Mar; 9(3):649-58. PMID: 11931771.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    85. Timchenko LT, Tapscott SJ, Cooper TA, Monckton DG. Myotonic dystrophy: discussion of molecular basis. Adv Exp Med Biol. 2002; 516:27-45. PMID: 12611434.
      Citations: 4     Fields:    Translation:HumansAnimals
    86. Stickeler E, Fraser SD, Honig A, Chen AL, Berget SM, Cooper TA. The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J. 2001 Jul 16; 20(14):3821-30. PMID: 11447123; PMCID: PMC125550.
      Citations: 79     Fields:    Translation:Cells
    87. Ladd AN, Charlet N, Cooper TA. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol. 2001 Feb; 21(4):1285-96. PMID: 11158314; PMCID: PMC99581.
      Citations: 194     Fields:    Translation:HumansAnimalsCells
    88. Ryan KJ, Charlet-B N, Cooper TA. Binding of PurH to a muscle-specific splicing enhancer functionally correlates with exon inclusion in vivo. J Biol Chem. 2000 Jul 07; 275(27):20618-26. PMID: 10801888.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    89. Philips AV, Cooper TA. RNA processing and human disease. Cell Mol Life Sci. 2000 Feb; 57(2):235-49. PMID: 10766020.
      Citations: 39     Fields:    Translation:HumansCells
    90. Stark JM, Cooper TA, Roth MB. The relative strengths of SR protein-mediated associations of alternative and constitutive exons can influence alternative splicing. J Biol Chem. 1999 Oct 15; 274(42):29838-42. PMID: 10514463.
      Citations: 4     Fields:    Translation:Cells
    91. Stoss O, Schwaiger FW, Cooper TA, Stamm S. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. J Biol Chem. 1999 Apr 16; 274(16):10951-62. PMID: 10196175.
      Citations: 15     Fields:    Translation:HumansCells
    92. Cooper TA. Defining pre-mRNA cis elements that regulate cell-specific splicing. Methods Mol Biol. 1999; 118:391-403. PMID: 10549538.
      Citations: 3     Fields:    Translation:Cells
    93. Cooper TA. In vivo SELEX in vertebrate cells. Methods Mol Biol. 1999; 118:405-17. PMID: 10549539.
      Citations: 2     Fields:    Translation:Cells
    94. Cooper TA. Muscle-specific splicing of a heterologous exon mediated by a single muscle-specific splicing enhancer from the cardiac troponin T gene. Mol Cell Biol. 1998 Aug; 18(8):4519-25. PMID: 9671461; PMCID: PMC109037.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    95. Philips AV, Timchenko LT, Cooper TA. Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science. 1998 May 01; 280(5364):737-41. PMID: 9563950.
      Citations: 349     Fields:    Translation:HumansCells
    96. Elrick LL, Humphrey MB, Cooper TA, Berget SM. A short sequence within two purine-rich enhancers determines 5' splice site specificity. Mol Cell Biol. 1998 Jan; 18(1):343-52. PMID: 9418881; PMCID: PMC121503.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    97. Cooper TA, Mattox W. The regulation of splice-site selection, and its role in human disease. Am J Hum Genet. 1997 Aug; 61(2):259-66. PMID: 9311728; PMCID: PMC1715899.
      Citations: 60     Fields:    Translation:HumansCells
    98. Coulter LR, Landree MA, Cooper TA. Identification of a new class of exonic splicing enhancers by in vivo selection. Mol Cell Biol. 1997 Apr; 17(4):2143-50. PMID: 9121463; PMCID: PMC232062.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    99. Ryan KJ, Cooper TA. Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol. 1996 Aug; 16(8):4014-23. PMID: 8754799; PMCID: PMC231397.
      Citations: 40     Fields:    Translation:AnimalsCells
    100. Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol. 1995 Sep; 15(9):4898-907. PMID: 7651409; PMCID: PMC230736.
      Citations: 98     Fields:    Translation:HumansCells
    101. Humphrey MB, Bryan J, Cooper TA, Berget SM. A 32-nucleotide exon-splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon. Mol Cell Biol. 1995 Aug; 15(8):3979-88. PMID: 7623794; PMCID: PMC230637.
      Citations: 42     Fields:    Translation:HumansCells
    102. Lee AB, Cooper TA. Improved direct PCR screen for bacterial colonies: wooden toothpicks inhibit PCR amplification. Biotechniques. 1995 Feb; 18(2):225-6. PMID: 7537048.
      Citations: 10     Fields:    
    103. Xu R, Teng J, Cooper TA. The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol. 1993 Jun; 13(6):3660-74. PMID: 8388541; PMCID: PMC359835.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    104. Cooper TA. In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron. J Biol Chem. 1992 Mar 15; 267(8):5330-8. PMID: 1544914.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
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