"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
|
Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
|
Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 5 | 2 | 7 |
1996 | 3 | 6 | 9 |
1997 | 1 | 5 | 6 |
1998 | 3 | 3 | 6 |
1999 | 8 | 5 | 13 |
2000 | 3 | 8 | 11 |
2001 | 7 | 3 | 10 |
2002 | 5 | 4 | 9 |
2003 | 1 | 4 | 5 |
2004 | 6 | 5 | 11 |
2005 | 11 | 10 | 21 |
2006 | 5 | 4 | 9 |
2007 | 7 | 2 | 9 |
2008 | 4 | 6 | 10 |
2009 | 3 | 10 | 13 |
2010 | 5 | 6 | 11 |
2011 | 3 | 2 | 5 |
2012 | 1 | 4 | 5 |
2013 | 6 | 3 | 9 |
2014 | 6 | 6 | 12 |
2015 | 6 | 1 | 7 |
2016 | 5 | 7 | 12 |
2017 | 3 | 1 | 4 |
2018 | 5 | 4 | 9 |
2019 | 1 | 4 | 5 |
2020 | 1 | 9 | 10 |
2021 | 1 | 2 | 3 |
2022 | 1 | 2 | 3 |
2023 | 3 | 3 | 6 |
2024 | 3 | 2 | 5 |
2025 | 1 | 2 | 3 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is altered in striated muscle diseases. RNA Biol. 2025 Dec; 22(1):1-20.
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Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms. Mol Cell. 2025 Apr 03; 85(7):1445-1466.e13.
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MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model. J Clin Invest. 2025 Feb 11; 135(7).
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Expression levels of core spliceosomal proteins modulate the MBNL-mediated spliceopathy in DM1. Hum Mol Genet. 2024 11 05; 33(21):1873-1886.
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Rescue of Scn5a mis-splicing does not improve the structural and functional heart defects of a DM1 heart mouse model. Hum Mol Genet. 2024 10 07; 33(20):1789-1799.
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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing. Nat Cell Biol. 2024 08; 26(8):1233-1246.
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HuR controls glutaminase RNA metabolism. Nat Commun. 2024 Jul 04; 15(1):5620.
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Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression. Nat Commun. 2024 May 03; 15(1):3732.
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Identification of Nonfunctional Alternatively Spliced Isoforms of STING in Human Acute Myeloid Leukemia. Cancer Res Commun. 2024 03 25; 4(3):911-918.
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Control of mammalian gene expression by modulation of polyA signal cleavage at 5' UTR. Nat Biotechnol. 2024 Sep; 42(9):1454-1466.