"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
| Descriptor ID |
D017398
|
| MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
|
| Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
|
Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 6 | 8 |
| 1997 | 0 | 5 | 5 |
| 1998 | 2 | 3 | 5 |
| 1999 | 8 | 4 | 12 |
| 2000 | 2 | 7 | 9 |
| 2001 | 3 | 3 | 6 |
| 2002 | 0 | 4 | 4 |
| 2003 | 1 | 4 | 5 |
| 2004 | 3 | 3 | 6 |
| 2005 | 7 | 9 | 16 |
| 2006 | 3 | 3 | 6 |
| 2007 | 4 | 2 | 6 |
| 2008 | 3 | 6 | 9 |
| 2009 | 2 | 7 | 9 |
| 2010 | 3 | 5 | 8 |
| 2011 | 2 | 2 | 4 |
| 2012 | 2 | 2 | 4 |
| 2013 | 4 | 2 | 6 |
| 2014 | 7 | 5 | 12 |
| 2015 | 7 | 1 | 8 |
| 2016 | 4 | 7 | 11 |
| 2017 | 4 | 2 | 6 |
| 2018 | 5 | 3 | 8 |
| 2019 | 3 | 3 | 6 |
| 2020 | 3 | 9 | 12 |
| 2021 | 2 | 3 | 5 |
| 2022 | 1 | 2 | 3 |
| 2023 | 3 | 3 | 6 |
| 2024 | 4 | 2 | 6 |
| 2025 | 3 | 4 | 7 |
| 2026 | 2 | 1 | 3 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome. Sci Transl Med. 2026 Mar 04; 18(839):eadq4529.
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Modified Polycyclic Compounds Rescue Mis-splicing in Myotonic Dystrophy Type 1 Disease Models. ACS Chem Biol. 2026 Mar 20; 21(3):502-518.
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De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders. Nat Commun. 2026 Jan 23; 17(1):1569.
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PTBP1 variants displaying altered nucleocytoplasmic distribution are responsible for a neurodevelopmental disorder with skeletal dysplasia. J Clin Invest. 2025 Nov 17; 135(22).
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Alternative splicing of KLF4 in myeloid cells: implications for cellular plasticity and trained immunity in cancer and inflammatory disease. Front Immunol. 2025; 16:1585528.
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Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is altered in striated muscle diseases. RNA Biol. 2025 12; 22(1):1-20.
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Integrating short-read and long-read single-cell RNA sequencing for comprehensive transcriptome profiling in mouse retina. Genome Res. 2025 04 14; 35(4):740-754.
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Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms. Mol Cell. 2025 Apr 03; 85(7):1445-1466.e13.
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MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model. J Clin Invest. 2025 Feb 11; 135(7).
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SNORA37/CMTR1/ELAVL1 feedback loop drives gastric cancer progression via facilitating?CD44 alternative splicing. J Exp Clin Cancer Res. 2025 Jan 16; 44(1):15.