"Mice, Inbred CFTR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.
| Descriptor ID |
D018181
|
| MeSH Number(s) |
B01.050.050.199.520.520.445 B01.050.150.900.649.313.992.635.505.500.400.445
|
| Concept/Terms |
Mice, Inbred CFTR- Mice, Inbred CFTR
- CFTR Mice, Inbred
- Inbred CFTR Mice
- Mouse, Inbred CFTR
- CFTR Mouse, Inbred
- Inbred CFTR Mouse
- Mice, CFTR
- CFTR Mice
- Mouse, CFTR
- CFTR Mouse
|
Below are MeSH descriptors whose meaning is more general than "Mice, Inbred CFTR".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred CFTR".
This graph shows the total number of publications written about "Mice, Inbred CFTR" by people in this website by year, and whether "Mice, Inbred CFTR" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Mice, Inbred CFTR" by people in Profiles.
-
Impact of heterozygote CFTR mutations in COPD patients with chronic bronchitis. Respir Res. 2014 Feb 11; 15:18.
-
CFTR dysfunction predisposes to fibrotic liver disease in a murine model. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15; 303(4):G474-81.
-
Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy. J Pediatr Surg. 2011 Jan; 46(1):33-8.
-
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol. 2010 Sep; 12(9):863-75.