"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
| Descriptor ID |
D019463
|
| MeSH Number(s) |
B01.050.050.199.520.520.555 B01.050.150.900.649.313.992.635.505.500.400.555
|
| Concept/Terms |
Mice, Inbred MRL lpr- Mice, Inbred MRL lpr
- Mouse, MRL lpr
- MRL lpr Mouse
- Mice, MRL lpr
- MRL lpr Mice
- Mouse, Inbred MRL lpr
|
Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred MRL lpr".
This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in this website by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 3 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles.
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Faslpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus. Clin Immunol. 2024 01; 258:109874.
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Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum. J Autoimmun. 2024 Jan; 142:103134.
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Ezh2 Knockout in B Cells Impairs Plasmablast Differentiation and Ameliorates Lupus-like Disease in MRL/lpr Mice. Arthritis Rheumatol. 2023 08; 75(8):1395-1406.
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Dependence on Autophagy for Autoreactive Memory B Cells in the Development of Pristane-Induced Lupus. Front Immunol. 2021; 12:701066.
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Kidney Level Lupus Nephritis Classification Using Uncertainty Guided Bayesian Convolutional Neural Networks. IEEE J Biomed Health Inform. 2021 02; 25(2):315-324.
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A highly potent lymphatic system-targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus. Sci Adv. 2020 06; 6(24):eabb3900.
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Curcumin Attenuates Both Acute and Chronic Immune Nephritis. Int J Mol Sci. 2020 Mar 04; 21(5).
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Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. Clin Immunol. 2016 08; 169:58-68.
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High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus. Am J Nephrol. 2015; 41(3):241-7.
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Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid. Arthritis Rheumatol. 2014 Nov; 66(11):3129-39.