"Trans-Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
| Descriptor ID |
D020040
|
| MeSH Number(s) |
G02.111.760.700.750 G03.839.700.750 G05.308.700.700.750
|
| Concept/Terms |
Trans-Splicing- Trans-Splicing
- Trans Splicing
- Splicing, Trans
- RNA Trans-Splicing
- RNA Trans Splicing
- Trans-Splicings, RNA
- Trans RNA Splicing
- RNA Splicing, Trans
|
Below are MeSH descriptors whose meaning is more general than "Trans-Splicing".
Below are MeSH descriptors whose meaning is more specific than "Trans-Splicing".
This graph shows the total number of publications written about "Trans-Splicing" by people in this website by year, and whether "Trans-Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Trans-Splicing" by people in Profiles.
-
Two splicing factors carrying serine-arginine motifs, TSR1 and TSR1IP, regulate splicing, mRNA stability, and rRNA processing in Trypanosoma brucei. RNA Biol. 2014; 11(6):715-31.
-
The hnRNP F/H homologue of Trypanosoma brucei is differentially expressed in the two life cycle stages of the parasite and regulates splicing and mRNA stability. Nucleic Acids Res. 2013 Jul; 41(13):6577-94.
-
Basal splicing factors regulate the stability of mature mRNAs in trypanosomes. J Biol Chem. 2013 Feb 15; 288(7):4991-5006.
-
Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis. Genome Res. 2012 Oct; 22(10):2079-87.
-
Multiple roles for polypyrimidine tract binding (PTB) proteins in trypanosome RNA metabolism. RNA. 2009 Apr; 15(4):648-65.
-
Naturally occurring heterologous trans-splicing of adenovirus RNA with host cellular transcripts during infection. FEBS Lett. 2002 Jul 03; 522(1-3):41-6.
-
Promiscuity of pre-mRNA spliceosome-mediated trans splicing: a problem for gene therapy? Hum Gene Ther. 2001 Jul 20; 12(11):1429-41.