CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
|
| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
|
| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
|
Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 1 | 3 |
| 1996 | 2 | 1 | 3 |
| 1997 | 2 | 2 | 4 |
| 1998 | 1 | 2 | 3 |
| 1999 | 1 | 1 | 2 |
| 2000 | 2 | 3 | 5 |
| 2001 | 2 | 3 | 5 |
| 2002 | 3 | 9 | 12 |
| 2003 | 3 | 6 | 9 |
| 2004 | 4 | 4 | 8 |
| 2005 | 7 | 4 | 11 |
| 2006 | 7 | 5 | 12 |
| 2007 | 8 | 11 | 19 |
| 2008 | 8 | 8 | 16 |
| 2009 | 10 | 4 | 14 |
| 2010 | 4 | 11 | 15 |
| 2011 | 6 | 11 | 17 |
| 2012 | 10 | 6 | 16 |
| 2013 | 9 | 6 | 15 |
| 2014 | 9 | 7 | 16 |
| 2015 | 5 | 7 | 12 |
| 2016 | 10 | 6 | 16 |
| 2017 | 9 | 7 | 16 |
| 2018 | 11 | 4 | 15 |
| 2019 | 4 | 5 | 9 |
| 2020 | 5 | 12 | 17 |
| 2021 | 3 | 8 | 11 |
| 2022 | 0 | 5 | 5 |
| 2023 | 0 | 7 | 7 |
| 2024 | 2 | 1 | 3 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma. Am J Physiol Lung Cell Mol Physiol. 2025 Mar 01; 328(3):L372-L378.
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Engineering immunity: bacterial delivery of cancer neoantigen vaccines. Trends Immunol. 2024 Dec; 45(12):931-933.
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CD4+ T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model. Proc Natl Acad Sci U S A. 2024 Nov 26; 121(48):e2407648121.
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HIF-2a-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis. Nat Commun. 2024 Sep 14; 15(1):8042.
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Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy. Nature. 2024 Aug; 632(8023):182-191.
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Radiotherapy in the treatment of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder. Int J Dermatol. 2025 Feb; 64(2):385-389.
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Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors. Cancer Cell. 2024 Jul 08; 42(7):1202-1216.e8.
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Phenotypic and functional characterization of posoleucel, a multivirus-specific T cell therapy for the treatment and prevention of viral infections in immunocompromised patients. Cytotherapy. 2024 Aug; 26(8):869-877.
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Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques. Nature. 2024 Feb; 626(7998):385-391.
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TLR2, TLR3, TLR4, TLR9 and TLR11 expression on effector CD4+ T-cell subsets in Leishmania donovani infection. Exp Parasitol. 2023 Dec; 255:108645.