"Chief Cells, Gastric" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Epithelial cells that line the basal half of the GASTRIC GLANDS. Chief cells synthesize and export an inactive enzyme PEPSINOGEN which is converted into the highly proteolytic enzyme PEPSIN in the acid environment of the STOMACH.
| Descriptor ID |
D019872
|
| MeSH Number(s) |
A03.556.875.875.440.150 A10.615.550.291.150 A11.436.150
|
| Concept/Terms |
Chief Cells, Gastric- Chief Cells, Gastric
- Chief Cell, Gastric
- Gastric Chief Cell
- Gastric Zymogenic Cells
- Cell, Gastric Zymogenic
- Cells, Gastric Zymogenic
- Gastric Zymogenic Cell
- Zymogenic Cell, Gastric
- Zymogenic Cells, Gastric
- Gastric Chief Cells
|
Below are MeSH descriptors whose meaning is more general than "Chief Cells, Gastric".
Below are MeSH descriptors whose meaning is more specific than "Chief Cells, Gastric".
This graph shows the total number of publications written about "Chief Cells, Gastric" by people in this website by year, and whether "Chief Cells, Gastric" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 3 | 1 | 4 |
| 2011 | 2 | 0 | 2 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chief Cells, Gastric" by people in Profiles.
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Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway. Dev Cell. 2024 May 06; 59(9):1175-1191.e7.
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SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cell Mol Gastroenterol Hepatol. 2023; 16(3):325-339.
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ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G49-G65.
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DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia. Gastroenterology. 2021 01; 160(1):260-271.e10.
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Single-Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus. Gastroenterology. 2020 12; 159(6):2116-2129.e4.
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Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia. Gastroenterology. 2020 02; 158(3):598-609.e5.
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Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury. Cell Mol Gastroenterol Hepatol. 2019; 8(3):379-405.
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Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. EMBO J. 2018 04 03; 37(7).
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Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells. Gastroenterology. 2018 03; 154(4):839-843.e2.
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Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach. Gastroenterology. 2017 03; 152(4):762-766.e7.