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MAKOTO FUKUDA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
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    Collapse Research 
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    R01DK126655     (FUKUDA, MAKOTO)Feb 15, 2021 - Nov 30, 2024
    NIH
    A Novel Neural Mechanism that Mediates the Therapeutic Effects of Metformin
    Role: Principal Investigator
    R01DK104901     (FUKUDA, MAKOTO)Sep 24, 2015 - Jul 31, 2021
    NIH
    Central Role of Gut Hormone GIP in Leptin Resistance and Obesity
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin HY, Lu W, He Y, Fu Y, Kaneko K, Huang P, De la Puente-Gomez AB, Wang C, Yang Y, Li F, Xu Y, Fukuda M. Low-dose metformin requires brain Rap1 for its antidiabetic action. Sci Adv. 2025 Aug; 11(31):eadu3700. PMID: 40737402.
      Citations:    
    2. Tu L, Fang X, Yang Y, Yu M, Liu H, Liu H, Yin N, Bean JC, Conde KM, Wang M, Li Y, Ginnard OZ, Liu Q, Shi Y, Han J, Zhu Y, Fukuda M, Tong Q, Arenkiel B, Xue M, He Y, Wang C, Xu Y. Vestibular neurons link motion sickness, behavioural thermoregulation and metabolic balance in mice. Nat Metab. 2025 Apr; 7(4):742-758. PMID: 40119169.
      Citations:    Fields:    Translation:AnimalsCells
    3. Kaneko K, Lu W, Xu Y, Morozov A, Fukuda M, Kaneko K, Lu W, Xu Y, Morozov A, Fukuda M. The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism. Mol Metab. 2025 May; 95:102117. PMID: 40024570; PMCID: PMC11938153.
      Citations:    Fields:    Translation:AnimalsCells
    4. Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarcelli NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu Y. Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. J Clin Invest. 2023 07 17; 133(14). PMID: 37261917; PMCID: PMC10348766.
      Citations:    Fields:    Translation:AnimalsCells
    5. Tu L, Fukuda M, Tong Q, Xu Y. The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis. Cell Biosci. 2022 May 26; 12(1):71. PMID: 35619170; PMCID: PMC9134642.
      Citations:    
    6. Yang Y, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Rep. 2021 12 07; 37(10):110075. PMID: 34879284; PMCID: PMC8715676.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Fukuda M. The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity. Diabetes. 2021 09; 70(9):1929-1937. PMID: 34176784; PMCID: PMC8576424.
      Citations: 1     Fields:    Translation:HumansAnimals
    8. Kaneko K, Lin HY, Fu Y, Saha PK, De la Puente-Gomez AB, Xu Y, Ohinata K, Chen P, Morozov A, Fukuda M. Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021 06 08; 6(11). PMID: 33974562; PMCID: PMC8262364.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. He Y, Liu H, Yin N, Yang Y, Wang C, Yu M, Liu H, Liang C, Wang J, Tu L, Zhang N, Wang L, He Y, Fukuda M, Wu Q, Sun Z, Tong Q, Xu Y. Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss. J Neurosci. 2021 06 30; 41(26):5734-5746. PMID: 34031163; PMCID: PMC8244968.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Wang C, Zhou W, He Y, Yang T, Xu P, Yang Y, Cai X, Wang J, Liu H, Yu M, Liang C, Yang T, Liu H, Fukuda M, Tong Q, Wu Q, Sun Z, He Y, Xu Y. AgRP neurons trigger long-term potentiation and facilitate food seeking. Transl Psychiatry. 2021 01 05; 11(1):11. PMID: 33414382; PMCID: PMC7791100.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Fu Y, Kaneko K, Lin HY, Mo Q, Xu Y, Suganami T, Ravn P, Fukuda M. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. 2020 09 01; 161(9). PMID: 32603429; PMCID: PMC7410368.
      Citations: 9     Fields:    Translation:AnimalsCells
    12. Qu N, He Y, Wang C, Xu P, Yang Y, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Sun Z, Fukuda M, Li Y, Tian Q, Xu Y. A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia. Mol Psychiatry. 2020 05; 25(5):1006-1021. PMID: 31485012; PMCID: PMC7056580.
      Citations: 23     Fields:    Translation:Animals
    13. Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. J Clin Invest. 2019 08 12; 129(9):3786-3791. PMID: 31403469; PMCID: PMC6715359.
      Citations: 29     Fields:    Translation:AnimalsCells
    14. Cordonier EL, Liu T, Saito K, Chen SS, Xu Y, Fukuda M. Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression. J Endocr Soc. 2019 Jul 01; 3(7):1246-1260. PMID: 31214662; PMCID: PMC6570635.
      Citations: 1     
    15. Kaneko K, Xu P, Cordonier EL, Chen SS, Ng A, Xu Y, Morozov A, Fukuda M. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Cell Rep. 2016 09 13; 16(11):3003-3015. PMID: 27626668; PMCID: PMC5024738.
      Citations: 19     Fields:    Translation:AnimalsCells
    16. Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton AO, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice. Sci Rep. 2016 Mar 18; 6:23459. PMID: 26988598; PMCID: PMC4796901.
      Citations: 25     Fields:    Translation:Animals
    17. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425; PMCID: PMC4655219.
      Citations: 23     Fields:    Translation:AnimalsCells
    18. Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton AO, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. Br J Pharmacol. 2015 Jul; 172(14):3510-21. PMID: 25817043; PMCID: PMC4507156.
      Citations: 5     Fields:    Translation:AnimalsCells
    19. Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042; PMCID: PMC4430614.
      Citations: 18     Fields:    Translation:Animals
    20. Jackson AC, Liu C, Fukuda M, Lazarus M, Gautron L. Neuroanatomy and transgenic technologies. Front Neuroanat. 2014; 8:157. PMID: 25653595; PMCID: PMC4301003.
      Citations:    
    21. Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE, Elmquist JK, Deng Z. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metab. 2014 Sep 02; 20(3):471-82. PMID: 25017942; PMCID: PMC4186248.
      Citations: 112     Fields:    Translation:AnimalsCells
    22. Aziz R, Beymer M, Newshan A, Yu G, Rosati B, McKinnon D, Fukuda M, Lin RZ, Mayer C, Boehm U, Negr?n AL, Acosta-Mart?nez M. Galanin-like peptide (GALP) neurone-specific phosphoinositide 3-kinase signalling regulates GALP mRNA levels in the hypothalamus of males and luteinising hormone levels in both sexes. J Neuroendocrinol. 2014 Jul; 26(7):426-38. PMID: 24796383; PMCID: PMC4076824.
      Citations: 3     Fields:    Translation:AnimalsCells
    23. Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, Sun K, Liu T, Harper MJ, Lee CE, Lee S, Scherer PE, Elmquist JK. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nat Commun. 2014 May 12; 5:3878. PMID: 24815961; PMCID: PMC4080408.
      Citations: 134     Fields:    Translation:AnimalsCells
    24. Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 2014 Jun; 57(6):1209-18. PMID: 24623101; PMCID: PMC4106234.
      Citations: 19     Fields:    Translation:AnimalsCells
    25. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 02; 18(1):86-98. PMID: 23823479; PMCID: PMC3752162.
      Citations: 37     Fields:    Translation:AnimalsCells
    26. Xu Y, Elmquist JK, Fukuda M. Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci. 2011 Dec; 1243:1-14. PMID: 22211889; PMCID: PMC3467098.
      Citations: 61     Fields:    Translation:HumansAnimals
    27. Fukuda M, Williams KW, Gautron L, Elmquist JK. Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab. 2011 Mar 02; 13(3):331-9. PMID: 21356522; PMCID: PMC3747952.
      Citations: 43     Fields:    Translation:AnimalsCells
    28. Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec; 13(12):1457-9. PMID: 21037584; PMCID: PMC3059249.
      Citations: 51     Fields:    Translation:AnimalsCells
    29. Donato J, Fukuda M, Vianna CR, Elias CF, Fraz?o R. Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology. 2010 Nov; 151(11):5415-27. PMID: 20881244; PMCID: PMC2954713.
      Citations: 23     Fields:    Translation:AnimalsCells
    30. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010 Jul 07; 12(1):88-95. PMID: 20620998; PMCID: PMC2919367.
      Citations: 57     Fields:    Translation:AnimalsCells
    31. Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, Rahmouni K, Coppari R. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 2010 Jul 07; 12(1):78-87. PMID: 20620997; PMCID: PMC2904327.
      Citations: 125     Fields:    Translation:AnimalsCells
    32. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Elmquist JK, Br?ning JC. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010 Apr 07; 11(4):286-97. PMID: 20374961; PMCID: PMC2854520.
      Citations: 191     Fields:    Translation:AnimalsCells
    33. Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov; 150(11):4874-82. PMID: 19819947; PMCID: PMC2775989.
      Citations: 49     Fields:    Translation:AnimalsCells
    34. Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK. Monitoring FoxO1 localization in chemically identified neurons. J Neurosci. 2008 Dec 10; 28(50):13640-8. PMID: 19074037; PMCID: PMC2615536.
      Citations: 48     Fields:    Translation:AnimalsCells
    35. Ookuma S, Fukuda M, Nishida E. Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr Biol. 2003 Mar 04; 13(5):427-31. PMID: 12620193.
      Citations: 21     Fields:    Translation:AnimalsCells
    36. Bamba C, Bobinnec Y, Fukuda M, Nishida E. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Curr Biol. 2002 Mar 19; 12(6):503-7. PMID: 11909538.
      Citations: 30     Fields:    Translation:AnimalsCells
    37. Matsubayashi Y, Fukuda M, Nishida E. Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells. J Biol Chem. 2001 Nov 09; 276(45):41755-60. PMID: 11546808.
      Citations: 50     Fields:    Translation:HumansCells
    38. Bobinnec Y, Fukuda M, Nishida E. Identification and characterization of Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated tissues. J Cell Sci. 2000 Nov; 113 Pt 21:3747-59. PMID: 11034903.
      Citations: 26     Fields:    Translation:AnimalsCells
    39. Watanabe M, Masuyama N, Fukuda M, Nishida E. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 2000 Aug; 1(2):176-82. PMID: 11265759; PMCID: PMC1084261.
      Citations: 30     Fields:    Translation:HumansCells
    40. Hashimoto H, Fukuda M, Matsuo Y, Yokoyama Y, Nishida E, Toyohara H, Sakaguchi M. Identification of a nuclear export signal in MKK6, an activator of the carp p38 mitogen-activated protein kinases. Eur J Biochem. 2000 Jul; 267(14):4362-71. PMID: 10880959.
      Citations: 4     Fields:    Translation:AnimalsCells
    41. Adachi M, Fukuda M, Nishida E. Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism. J Cell Biol. 2000 Mar 06; 148(5):849-56. PMID: 10704436; PMCID: PMC2174544.
      Citations: 62     Fields:    Translation:AnimalsCells
    42. Adachi M, Fukuda M, Nishida E. Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J. 1999 Oct 01; 18(19):5347-58. PMID: 10508167; PMCID: PMC1171604.
      Citations: 66     Fields:    Translation:AnimalsCells
    43. Miki H, Fukuda M, Nishida E, Takenawa T. Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling. J Biol Chem. 1999 Sep 24; 274(39):27605-9. PMID: 10488099.
      Citations: 17     Fields:    Translation:AnimalsCells
    44. Watanabe M, Fukuda M, Yoshida M, Yanagida M, Nishida E. Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast. Genes Cells. 1999 May; 4(5):291-7. PMID: 10421839.
      Citations: 19     Fields:    Translation:AnimalsCells
    45. Gotoh I, Fukuda M, Adachi M, Nishida E. Control of the cell morphology and the S phase entry by mitogen-activated protein kinase kinase. A regulatory role of its n-terminal region. J Biol Chem. 1999 Apr 23; 274(17):11874-80. PMID: 10207007.
      Citations: 5     Fields:    Translation:AnimalsCells
    46. Toyoshima F, Moriguchi T, Wada A, Fukuda M, Nishida E. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J. 1998 May 15; 17(10):2728-35. PMID: 9582266; PMCID: PMC1170613.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    47. Wada A, Fukuda M, Mishima M, Nishida E. Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein. EMBO J. 1998 Mar 16; 17(6):1635-41. PMID: 9501085; PMCID: PMC1170511.
      Citations: 73     Fields:    Translation:AnimalsCells
    48. Yoneyama M, Suhara W, Fukuhara Y, Fukuda M, Nishida E, Fujita T. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J. 1998 Feb 16; 17(4):1087-95. PMID: 9463386; PMCID: PMC1170457.
      Citations: 309     Fields:    Translation:HumansAnimalsCells
    49. Fukuda M, Gotoh I, Adachi M, Gotoh Y, Nishida E. A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase. J Biol Chem. 1997 Dec 19; 272(51):32642-8. PMID: 9405481.
      Citations: 41     Fields:    Translation:AnimalsCells
    50. Fukuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M, Nishida E. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature. 1997 Nov 20; 390(6657):308-11. PMID: 9384386.
      Citations: 493     Fields:    Translation:HumansAnimalsCells
    51. Fukuda M, Gotoh Y, Nishida E. Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J. 1997 Apr 15; 16(8):1901-8. PMID: 9155016; PMCID: PMC1169793.
      Citations: 111     Fields:    Translation:AnimalsCells
    52. Fukuda M, Gotoh I, Gotoh Y, Nishida E. Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal. J Biol Chem. 1996 Aug 16; 271(33):20024-8. PMID: 8702720.
      Citations: 97     Fields:    Translation:AnimalsCells
    53. Fukuda M, Gotoh Y, Tachibana T, Dell K, Hattori S, Yoneda Y, Nishida E. Induction of neurite outgrowth by MAP kinase in PC12 cells. Oncogene. 1995 Jul 20; 11(2):239-44. PMID: 7624141.
      Citations: 30     Fields:    Translation:AnimalsCells
    54. Fukuda M, Gotoh Y, Kosako H, Hattori S, Nishida E. Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes. J Biol Chem. 1994 Dec 30; 269(52):33097-101. PMID: 7806537.
      Citations: 3     Fields:    Translation:AnimalsCells
    55. Hattori S, Fukuda M, Yamashita T, Nakamura S, Gotoh Y, Nishida E. Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system. J Biol Chem. 1992 Oct 05; 267(28):20346-51. PMID: 1328197.
      Citations: 29     Fields:    Translation:AnimalsCells
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