"Leptin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
| Descriptor ID |
D020738
|
| MeSH Number(s) |
D06.472.699.042.500 D12.644.276.024.500 D12.644.548.011.500 D12.776.467.024.500 D23.529.024.500
|
| Concept/Terms |
Leptin- Leptin
- Obese Protein
- Obese Gene Product
- Gene Product, Obese
- Ob Gene Product
- Gene Product, Ob
- Ob Protein
|
Below are MeSH descriptors whose meaning is more general than "Leptin".
Below are MeSH descriptors whose meaning is more specific than "Leptin".
This graph shows the total number of publications written about "Leptin" by people in this website by year, and whether "Leptin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 3 | 3 |
| 1999 | 0 | 2 | 2 |
| 2000 | 1 | 3 | 4 |
| 2001 | 2 | 1 | 3 |
| 2002 | 1 | 2 | 3 |
| 2003 | 2 | 0 | 2 |
| 2004 | 4 | 1 | 5 |
| 2005 | 3 | 3 | 6 |
| 2006 | 4 | 5 | 9 |
| 2007 | 1 | 4 | 5 |
| 2008 | 2 | 3 | 5 |
| 2009 | 2 | 2 | 4 |
| 2010 | 7 | 10 | 17 |
| 2011 | 4 | 4 | 8 |
| 2012 | 5 | 4 | 9 |
| 2013 | 2 | 4 | 6 |
| 2014 | 3 | 3 | 6 |
| 2015 | 4 | 5 | 9 |
| 2016 | 6 | 1 | 7 |
| 2017 | 0 | 5 | 5 |
| 2018 | 1 | 2 | 3 |
| 2019 | 1 | 3 | 4 |
| 2020 | 5 | 3 | 8 |
| 2021 | 1 | 2 | 3 |
| 2022 | 1 | 3 | 4 |
| 2023 | 3 | 3 | 6 |
| 2024 | 1 | 1 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leptin" by people in Profiles.
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The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism. Mol Metab. 2025 May; 95:102117.
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Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake. Geroscience. 2024 Oct; 46(5):4809-4826.
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Leptin deficiency, a potential mechanism for impaired fetal lung development in uteroplacental insufficiency? Pediatr Res. 2024 May; 95(6):1410-1411.
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Leptin Decreases Gluconeogenesis and Gluconeogenic Substrate Availability in Patients With Lipodystrophy. J Clin Endocrinol Metab. 2023 12 21; 109(1):e209-e215.
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Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders. Sci Transl Med. 2023 11 22; 15(723):eade8460.
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Baseline leptin predicts response to metformin in adolescents with type 1 diabetes and increased body mass index. Diabetes Obes Metab. 2023 11; 25(11):3420-3423.
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The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challenges. Orphanet J Rare Dis. 2023 05 26; 18(1):127.
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Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity. Elife. 2023 04 12; 12.
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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. Nat Metab. 2023 01; 5(1):147-164.
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Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy. Cancer Res Commun. 2022 07; 2(7):694-705.