"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
| Descriptor ID |
D007515
|
| MeSH Number(s) |
A03.734.414 A06.407.414
|
| Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
|
Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 4 | 1 | 5 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 1 | 2 |
| 1998 | 1 | 1 | 2 |
| 1999 | 2 | 1 | 3 |
| 2000 | 2 | 2 | 4 |
| 2001 | 1 | 1 | 2 |
| 2002 | 4 | 0 | 4 |
| 2003 | 2 | 1 | 3 |
| 2004 | 1 | 6 | 7 |
| 2005 | 7 | 0 | 7 |
| 2006 | 4 | 2 | 6 |
| 2007 | 1 | 1 | 2 |
| 2008 | 4 | 1 | 5 |
| 2009 | 1 | 4 | 5 |
| 2010 | 2 | 1 | 3 |
| 2011 | 2 | 1 | 3 |
| 2012 | 4 | 0 | 4 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 3 | 4 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 1 | 3 | 4 |
| 2019 | 2 | 2 | 4 |
| 2020 | 3 | 0 | 3 |
| 2021 | 3 | 3 | 6 |
| 2022 | 2 | 0 | 2 |
| 2023 | 2 | 0 | 2 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Random C-Peptide and Islet Antibodies at Onset Predict ? Cell Function Trajectory and Insulin Dependence in Pediatric Diabetes. Endocr Pract. 2024 Dec; 30(12):1149-1157.
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Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease. Cell Metab. 2024 Jul 02; 36(7):1619-1633.e5.
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Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet. J Endocrinol. 2024 Apr 01; 261(1).
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Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection. Nat Commun. 2023 Nov 22; 14(1):7630.
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Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023 11 01; 46(11):1908-1915.
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Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion. Am J Physiol Endocrinol Metab. 2023 06 01; 324(6):E577-E588.
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Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats. Nat Commun. 2022 12 26; 13(1):7951.
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Beyond the "3 Ps": A critical appraisal of the non-endocrine manifestations of multiple endocrine neoplasia type 1. Front Endocrinol (Lausanne). 2022; 13:1029041.
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Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models. Sci Transl Med. 2022 10 05; 14(665):eabn1716.
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Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas. Dis Model Mech. 2022 08 01; 15(8).