rap1 GTP-Binding Proteins
"rap1 GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A genetically related subfamily of RAP GTP-BINDING PROTEINS that share homology with RAS PROTEINS. They bind to Ras effectors but do not activate them, therefore they may antagonize the effects of RAS PROTEINS. This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D020827
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.475.100 D12.644.360.525.475.100 D12.776.157.325.515.475.100 D12.776.476.525.475.100
|
| Concept/Terms |
rap1 GTP-Binding Protein- rap1 GTP-Binding Protein
- GTP-Binding Protein, rap1
- rap1 GTP Binding Protein
- rap1A Protein
- smg p21 GTP-Binding Protein
- smg p21 GTP Binding Protein
- smg p21A Protein
- p21A Protein, smg
- rap1A GTP-Binding Protein
- GTP-Binding Protein, rap1A
- rap1A GTP Binding Protein
- Krev-1 GTP-Binding Protein
- GTP-Binding Protein, Krev-1
- Krev 1 GTP Binding Protein
- SMG p21A GTP-Binding Protein
- SMG p21A GTP Binding Protein
- Krev-1 Protein
- Krev 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "rap1 GTP-Binding Proteins".
Below are MeSH descriptors whose meaning is more specific than "rap1 GTP-Binding Proteins".
This graph shows the total number of publications written about "rap1 GTP-Binding Proteins" by people in this website by year, and whether "rap1 GTP-Binding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "rap1 GTP-Binding Proteins" by people in Profiles.
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Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021 06 08; 6(11).
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Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. J Clin Invest. 2019 08 12; 129(9):3786-3791.
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Epac1 interacts with importin ?1 and controls neurite outgrowth independently of cAMP and Rap1. Sci Rep. 2016 11 03; 6:36370.
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Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Cell Rep. 2016 09 13; 16(11):3003-3015.
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Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3036-41.
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The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol. 2015 Jan; 17(1):81-94.
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Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest. 2014 Apr; 124(4):1757-69.
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The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling. J Clin Invest. 2012 Oct; 122(10):3579-92.
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miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. PLoS One. 2012; 7(6):e39167.
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Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab. 2011 Mar 02; 13(3):331-9.