rap1 GTP-Binding Proteins
"rap1 GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A genetically related subfamily of RAP GTP-BINDING PROTEINS that share homology with RAS PROTEINS. They bind to Ras effectors but do not activate them, therefore they may antagonize the effects of RAS PROTEINS. This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D020827
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.475.100 D12.644.360.525.475.100 D12.776.157.325.515.475.100 D12.776.476.525.475.100
|
| Concept/Terms |
rap1 GTP-Binding Protein- rap1 GTP-Binding Protein
- GTP-Binding Protein, rap1
- rap1 GTP Binding Protein
- rap1A Protein
- smg p21 GTP-Binding Protein
- smg p21 GTP Binding Protein
- smg p21A Protein
- p21A Protein, smg
- rap1A GTP-Binding Protein
- GTP-Binding Protein, rap1A
- rap1A GTP Binding Protein
- Krev-1 GTP-Binding Protein
- GTP-Binding Protein, Krev-1
- Krev 1 GTP Binding Protein
- SMG p21A GTP-Binding Protein
- SMG p21A GTP Binding Protein
- Krev-1 Protein
- Krev 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "rap1 GTP-Binding Proteins".
Below are MeSH descriptors whose meaning is more specific than "rap1 GTP-Binding Proteins".
This graph shows the total number of publications written about "rap1 GTP-Binding Proteins" by people in this website by year, and whether "rap1 GTP-Binding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "rap1 GTP-Binding Proteins" by people in Profiles.
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Low-dose metformin requires brain Rap1 for its antidiabetic action. Sci Adv. 2025 Aug; 11(31):eadu3700.
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The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism. Mol Metab. 2025 May; 95:102117.
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Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021 06 08; 6(11).
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Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. J Clin Invest. 2019 08 12; 129(9):3786-3791.
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Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Cell Rep. 2016 09 13; 16(11):3003-3015.
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Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest. 2014 Apr; 124(4):1757-69.
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Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab. 2011 Mar 02; 13(3):331-9.
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Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci. 2010 Sep 22; 30(38):12806-15.
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MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7181-6.
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Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer. Clin Cancer Res. 2006 Oct 01; 12(19):5720-5.