Dual-Specificity Phosphatases
"Dual-Specificity Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.
| Descriptor ID |
D054637
|
| MeSH Number(s) |
D08.811.277.352.650.625.225 D08.811.277.352.650.775.250 D08.811.641.755 D12.644.360.268 D12.776.476.268
|
| Concept/Terms |
Dual-Specificity Phosphatases- Dual-Specificity Phosphatases
- Dual Specificity Phosphatases
- Phosphatases, Dual-Specificity
- Dual-Specificity Phosphatase
- Dual Specificity Phosphatase
- Phosphatase, Dual-Specificity
- DUSP Phosphatases
- Phosphatases, DUSP
|
Below are MeSH descriptors whose meaning is more general than "Dual-Specificity Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Dual-Specificity Phosphatases".
This graph shows the total number of publications written about "Dual-Specificity Phosphatases" by people in this website by year, and whether "Dual-Specificity Phosphatases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 3 | 0 | 3 |
| 2016 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dual-Specificity Phosphatases" by people in Profiles.
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NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 06; 6:e1841.
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MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice. J Immunol. 2014 Apr 15; 192(8):3686-96.
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Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk. Carcinogenesis. 2013 Apr; 34(4):885-92.
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Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010 Sep 02; 29(35):4938-46.
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Oxidative stress in NSC-741909-induced apoptosis of cancer cells. J Transl Med. 2010 Apr 16; 8:37.
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MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem Biophys Res Commun. 2005 May 06; 330(2):511-8.