Peroxisomal Multifunctional Protein-2
"Peroxisomal Multifunctional Protein-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
| Descriptor ID |
D064029
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| MeSH Number(s) |
D08.811.520.241.300.275.500 D08.811.641.812 D08.811.682.047.436.375.640 D08.811.682.047.820.150.926
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| Concept/Terms |
Peroxisomal Multifunctional Protein-2- Peroxisomal Multifunctional Protein-2
- Multifunctional Protein-2, Peroxisomal
- Peroxisomal Multifunctional Protein 2
- 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
- Peroxisomal Multifunctional Enzyme Type 2
- 17-beta-Hydroxysteroid Dehydrogenase 4
- 17 beta Hydroxysteroid Dehydrogenase 4
- 4, 17-beta-Hydroxysteroid Dehydrogenase
- Dehydrogenase 4, 17-beta-Hydroxysteroid
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Below are MeSH descriptors whose meaning is more general than "Peroxisomal Multifunctional Protein-2".
Below are MeSH descriptors whose meaning is more specific than "Peroxisomal Multifunctional Protein-2".
This graph shows the total number of publications written about "Peroxisomal Multifunctional Protein-2" by people in this website by year, and whether "Peroxisomal Multifunctional Protein-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Peroxisomal Multifunctional Protein-2" by people in Profiles.
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A Novel Mechanism to Drive Castration-Resistant Prostate Cancer. Trends Endocrinol Metab. 2018 06; 29(6):366-368.
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Mini-Exome Coupled to Read-Depth Based Copy Number Variation Analysis in Patients with Inherited Ataxias. Hum Mutat. 2016 12; 37(12):1340-1353.
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Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chem Biol. 2006 Mar; 13(3):241-9.