"Phosphofructokinase-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
| Descriptor ID |
D025481
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| MeSH Number(s) |
D08.811.277.352.650.622 D08.811.641.843 D08.811.913.696.620.225.850.750
|
| Concept/Terms |
Phosphofructokinase-2- Phosphofructokinase-2
- Phosphofructokinase 2
- ATP-D-Fructose-6-phosphate 2-phosphotransferase
- 6-Phosphofructo-2-kinase
- Fructose-6-P,2-kinase
- Fructose-6-phosphate,2-kinase
- 6PF2K
- Fru-6-P,2-kinase
Fructose-2,6-bisphosphatase- Fructose-2,6-bisphosphatase
- Fructose-2,6-bisphosphate 2-phosphatase
- fructose-2,6-diphosphatase
- Fructose 2,6-bisphosphatase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase- 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
- 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
- Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
- 6-PF-2-K-Fru-2,6-P(2)ase
- F Kinase-F-bisphosphatase
- Fru-kinase-Fru-bisphosphatase
|
Below are MeSH descriptors whose meaning is more general than "Phosphofructokinase-2".
Below are MeSH descriptors whose meaning is more specific than "Phosphofructokinase-2".
This graph shows the total number of publications written about "Phosphofructokinase-2" by people in this website by year, and whether "Phosphofructokinase-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphofructokinase-2" by people in Profiles.
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An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Cell Rep. 2024 01 23; 43(1):113557.
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Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Lett. 2021 10 10; 518:230-242.
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MiR-302 Regulates Glycolysis to Control Cell-Cycle during Neural Tube Closure. Int J Mol Sci. 2020 Oct 13; 21(20).
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6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers. Clin Cancer Res. 2019 09 15; 25(18):5702-5716.
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EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Mol Cell. 2018 04 19; 70(2):197-210.e7.
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Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254.
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Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells. Oncotarget. 2017 Mar 14; 8(11):17960-17980.
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Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct; 9(10):e1003900.
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Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010 May 07; 395(3):395-400.