"Multifunctional Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Molecules that contain multiple active sites which are used to catalyze more than one enzymatic reaction. Proteins in this class generally contain multiple active sites within a single peptide chain and may also contain more than one enzymatically active subunit. They are distinguished from MULTIENZYME COMPLEXES in that their subunits are not found as distinct enzymes.
| Descriptor ID |
D064251
|
| MeSH Number(s) |
D08.811.641
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Multifunctional Enzymes".
Below are MeSH descriptors whose meaning is more specific than "Multifunctional Enzymes".
This graph shows the total number of publications written about "Multifunctional Enzymes" by people in this website by year, and whether "Multifunctional Enzymes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 3 | 0 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "Multifunctional Enzymes" by people in Profiles.
-
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma. Oncogene. 2019 08; 38(34):6211-6225.
-
Atlas of Subcellular RNA Localization Revealed by APEX-Seq. Cell. 2019 07 11; 178(2):473-490.e26.
-
Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. J Natl Cancer Inst. 2019 Jun 01; 111(6):584-596.
-
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6.
-
Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017 07 15; 31(14):1469-1482.
-
DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science. 2014 Nov 28; 346(6213):1127-30.
-
Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology. BMC Med Genet. 2013 Aug 16; 14:83.
-
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science. 2010 Aug 06; 329(5992):693-6.
-
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell. 2010 Jul 09; 39(1):36-47.
-
Normal mode refinement of anisotropic thermal parameters for a supramolecular complex at 3.42-A crystallographic resolution. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7869-74.