"Isoenzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
| Descriptor ID |
D007527
|
| MeSH Number(s) |
D08.811.348 D12.776.800.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Isoenzymes".
Below are MeSH descriptors whose meaning is more specific than "Isoenzymes".
This graph shows the total number of publications written about "Isoenzymes" by people in this website by year, and whether "Isoenzymes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 1 | 3 |
| 1996 | 6 | 2 | 8 |
| 1997 | 3 | 3 | 6 |
| 1998 | 5 | 0 | 5 |
| 1999 | 3 | 9 | 12 |
| 2000 | 1 | 6 | 7 |
| 2001 | 6 | 7 | 13 |
| 2002 | 3 | 7 | 10 |
| 2003 | 14 | 16 | 30 |
| 2004 | 4 | 5 | 9 |
| 2005 | 0 | 3 | 3 |
| 2006 | 2 | 3 | 5 |
| 2007 | 0 | 9 | 9 |
| 2008 | 3 | 4 | 7 |
| 2009 | 2 | 6 | 8 |
| 2010 | 1 | 6 | 7 |
| 2011 | 1 | 4 | 5 |
| 2012 | 0 | 2 | 2 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 3 | 4 |
| 2015 | 0 | 3 | 3 |
| 2016 | 0 | 3 | 3 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 4 | 4 |
To return to the timeline,
click here.
Below are the most recent publications written about "Isoenzymes" by people in Profiles.
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A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells. J Biol Chem. 2022 01; 298(1):101441.
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The concurrence of DNA methylation and demethylation is associated with transcription regulation. Nat Commun. 2021 09 06; 12(1):5285.
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Bi-allelic KARS1 pathogenic variants affecting functions of cytosolic and mitochondrial isoforms are associated with a progressive and multisystem disease. Hum Mutat. 2021 06; 42(6):745-761.
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Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia. J Exp Med. 2021 05 03; 218(5).
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A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).
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Cyclic nucleotide selectivity of protein kinase G isozymes. Protein Sci. 2021 02; 30(2):316-327.
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The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation. Genes Dev. 2020 11 01; 34(21-22):1546-1558.
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Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability. Int J Mol Sci. 2019 May 30; 20(11).
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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell. 2019 06 20; 74(6):1123-1137.e6.
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Protein Kinase C Quality Control by Phosphatase PHLPP1?Unveils Loss-of-Function Mechanism in Cancer. Mol Cell. 2019 04 18; 74(2):378-392.e5.