"Holoenzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Catalytically active enzymes that are formed by the combination of an apoenzyme (APOENZYMES) and its appropriate cofactors and prosthetic groups.
| Descriptor ID |
D020035
|
| MeSH Number(s) |
D08.811.255
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Holoenzymes".
Below are MeSH descriptors whose meaning is more specific than "Holoenzymes".
This graph shows the total number of publications written about "Holoenzymes" by people in this website by year, and whether "Holoenzymes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 1 | 2 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Holoenzymes" by people in Profiles.
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Real-time observation of polymerase-promoter contact remodeling during transcription initiation. Nat Commun. 2017 10 27; 8(1):1178.
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The DNA polymerase III holoenzyme contains ? and is not a trimeric polymerase. Nucleic Acids Res. 2016 Feb 18; 44(3):1285-97.
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Realizing the allosteric potential of the tetrameric protein kinase A RIa holoenzyme. Structure. 2011 Feb 09; 19(2):265-76.
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Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. J Mol Biol. 2009 Nov 13; 393(5):1070-82.
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Super DksAs: substitutions in DksA enhancing its effects on transcription initiation. EMBO J. 2009 Jun 17; 28(12):1720-31.
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Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta. 2008 Jan; 1784(1):16-26.
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PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 2007 Sep 21; 130(6):1032-43.
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Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome. Am J Hum Genet. 2006 Nov; 79(5):878-89.
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Dynamics of signaling by PKA. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):25-37.
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Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant microphthalmia with linear skin defects (MLS) syndrome. Hum Mol Genet. 2002 Dec 01; 11(25):3237-48.