Fatty Acid Synthase, Type I
"Fatty Acid Synthase, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Animal form of fatty acid synthase which is encoded by a single gene and consists of seven catalytic domains and is functional as a homodimer. It is overexpressed in some NEOPLASMS and is a target in humans of some ANTINEOPLASTIC AGENTS and some ANTI-OBESITY AGENTS.
| Descriptor ID |
D054890
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| MeSH Number(s) |
D08.811.277.352.897.387.100 D08.811.520.241.300.287.099 D08.811.641.758 D08.811.682.047.820.196.500.099 D08.811.913.050.134.029.500.100 D08.811.913.050.170.500.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fatty Acid Synthase, Type I".
Below are MeSH descriptors whose meaning is more specific than "Fatty Acid Synthase, Type I".
This graph shows the total number of publications written about "Fatty Acid Synthase, Type I" by people in this website by year, and whether "Fatty Acid Synthase, Type I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fatty Acid Synthase, Type I" by people in Profiles.
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Caveolin-1 regulates hormone resistance through lipid synthesis, creating novel therapeutic opportunities for castration-resistant prostate cancer. Oncotarget. 2016 Jul 19; 7(29):46321-46334.
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Physiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014 Dec 24; 9(6):2180-91.
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Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma. Int J Mol Med. 2014 Mar; 33(3):633-9.
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Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer. FEBS J. 2012 Jul; 279(13):2399-411.
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A quantitative proteomic analysis of FFPE melanoma. J Cutan Pathol. 2011 Nov; 38(11):933-6.
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Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6. Clin Cancer Res. 2011 Apr 01; 17(7):1796-806.
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Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands. Proteins. 2008 Mar; 70(4):1228-34.